PMID: 7545450Jun 1, 1995Paper

Warfarin pretreatment does not lead to increased bleeding tendency during cardiac surgery

Journal of Cardiothoracic and Vascular Anesthesia
Wulf DietrichJ A Richter

Abstract

To study the influence of preoperative warfarin anticoagulation on postoperative blood loss and allogeneic blood requirement. Retrospective study with a matched control group. University and community hospital, single institutional. 240 patients scheduled for cardiac surgery. Warfarin sodium was administered to 125 patients preoperatively to prevent thromboembolic complications of their underlying heart disease, 115 served as control. Approximately half of the patients in each group received aprotinin treatment during operation. The international normalized ratio (INR) of the prothrombin time was preoperatively 2.4 (95% confidence interval [CI 0.95]: 2.3 to 2.6) in the warfarin group and 1.1 (CI 0.95: 1.0 to 1.1) in the control group (p < 0.05), and postoperatively 1.9 (CI 0.95: 1.8 to 2.1) (warfarin) and 1.5 (CI 0.95: 1.4 to 1.5) (control) (p < 0.05). The postoperative blood loss after 6 and 12 hours was 381 (CI 0.95: 329 to 434)/505 (CI 0.95: 439 to 571) mL (warfarin) compared with 472 (CI 0.95: 403 to 541)/612 (CI 0.95: 527 to 697) mL (control) (p < 0.05). This difference was blunted when the proteinase inhibitor aprotinin was used. Neither preoperative nor postoperative prothrombin time correlated with blood loss. Despite l...Continue Reading

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Citations

Mar 1, 1996·The Annals of Thoracic Surgery·B P Bidstrup
Aug 9, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·J Alcalay
Jan 1, 1997·Acta Anaesthesiologica Scandinavica·R E BarnetteV Jeevanandam
Dec 21, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ruth Dorothee HolzmannCarl Frank Schanbacher
Feb 15, 2013·Anesthesia and Analgesia·Alan Finley, Charles Greenberg
Mar 13, 2014·Annales Françaises D'anesthèsie Et De Rèanimation·M DurandC Poquet
Aug 29, 2006·Neurologic Clinics·Melissa J ArmstrongJosé Biller
Nov 28, 2006·The Annals of Thoracic Surgery·Parwis MassoudyHeinz Jakob
Oct 18, 2005·The British Journal of Dermatology·J M AmiciA Taïeb
May 18, 2012·Transfusion·Michael Desborough, Simon Stanworth
Jul 13, 2012·Journal of Plastic Surgery and Hand Surgery·Masayuki OkochiHirotaka Asato
Aug 12, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·C F Schanbacher, R G Bennett
Feb 26, 2003·Circulation·Brian S DonahueAlfred L George
Dec 2, 2008·Journal of Cardiac Surgery·Parwis MassoudyHeinz Jakob
May 12, 1998·Vascular Medicine·A K RaoR Kaplan
Aug 23, 2003·The British Journal of Dermatology·A Ah-WengJ A A Langtry
Sep 3, 2020·Journal of Cardiovascular Electrophysiology·Richard G TrohmanParikshit S Sharma
Sep 22, 2001·The Annals of Thoracic Surgery·C D MorrisK R Kanter

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