Warfarin reversal in anticoagulant-associated intracerebral hemorrhage.

Neurocritical Care
Joshua N GoldsteinLee H Schwamm

Abstract

Anticoagulant-associated intracerebral hemorrhage (ICH) is a devastating disease, causing death in half of patients and permanent disability in the majority of survivors. The finding that patients often continue bleeding after hospital presentation offers the possibility that emergency warfarin reversal may improve outcomes. As no clinical trials have demonstrated the superiority of any one treatment strategy, various treatment options are available. Intravenous vitamin K is the definitive therapy; however, as monotherapy it can require many hours to take effect. Therefore, it is often considered an adjunct agent. Coagulation factors can be repleted with fresh frozen plasma (FFP), which is widely available and relatively low cost, but can require substantial time to deliver in real-world settings. A number of coagulation factor products collectively termed prothrombin complex concentrates (PCCs) are widely available that can rapidly provide many or all the vitamin K-dependent coagulation factors. Recombinant activated factor VII is used in many centers for this purpose, as it is thought to provide a procoagulant effect that may compensate for the lack of the other critical factors. Until clinical trials demonstrate the superior...Continue Reading

References

Jul 1, 1992·Stroke; a Journal of Cerebral Circulation·K FredrikssonL G Strömblad
Aug 1, 1985·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A A DixonJ B Garner
Jan 1, 1994·Journal of Neurosurgery·Y FujiiO Sasaki
Jan 1, 1996·Seminars in Thrombosis and Hemostasis·T StaudingerM Frass
Jun 3, 1998·British Journal of Haematology
Jun 17, 1998·Stroke; a Journal of Cerebral Circulation·Y FujiiR Tanaka
Feb 7, 2001·Chest·J AnsellD Matchar
Feb 24, 2001·British Journal of Neurosurgery·M CartmillP O Byrne
May 11, 2001·The New England Journal of Medicine·A I QureshiD F Hanley
Jun 15, 2001·Journal of Thrombosis and Thrombolysis·L D FioreM T Brophy
Nov 2, 2002·Stroke; a Journal of Cerebral Circulation·James M GebelJoseph P Broderick
Nov 2, 2002·Stroke; a Journal of Cerebral Circulation·James M GebelJoseph P Broderick
Dec 3, 2002·Annals of Internal Medicine·Ruby Anne E Deveras, Craig M Kessler
Mar 1, 2003·The Journal of Emergency Medicine·Christina Wjasow, Robert McNamara
Jul 10, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Benny SørensenJørgen Ingerslev
Nov 5, 2003·Annals of Internal Medicine·Maureane Hoffman
Feb 5, 2004·Journal of Thrombosis and Thrombolysis·Mark A Crowther, Sarah Wilson
Feb 18, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Thomas Hanslik, Jacques Prinseau
Apr 28, 2004·Archives of Internal Medicine·Jonathan RosandSteven M Greenberg
Jun 17, 2004·British Journal of Haematology·D F O'ShaughnessyUNKNOWN British Committee for Standards in Haematology, Blood Transfusion Task Force
Aug 21, 2004·Transfusion·Walter Dzik, Arjun Rao
Sep 4, 2004·Neurosurgical Focus·Alfredo Quinones-HinojosaMichael T Lawton
Oct 29, 2004·Journal of Clinical Pathology·J P Hanley
Nov 2, 2004·The Medical Journal of Australia·Ross I BakerUNKNOWN Warfarin Reversal Consensus Group
Feb 25, 2005·The New England Journal of Medicine·Stephan A MayerUNKNOWN Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators
Sep 15, 2005·Neurocritical Care·David L BrodyMichael N Diringer
Nov 25, 2005·Stroke; a Journal of Cerebral Circulation·Joshua N GoldsteinJonathan Rosand
Dec 13, 2005·Seminars in Neurology·Amytis TowfighiJonathan Rosand
Dec 20, 2005·Lancet Neurology·Guohua XiJulian T Hoff

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Citations

Aug 11, 2010·Archives of Neurology·Joshua N GoldsteinLee H Schwamm
Jan 12, 2011·Current Treatment Options in Neurology·Joshua N Goldstein, Aaron J Gilson
Dec 6, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·H Bart Brouwers, Joshua N Goldstein
Jan 14, 2010·Critical Care Medicine·Paul Nyquist
Mar 18, 2011·Blood·Lawrence Tim Goodnough, Aryeh Shander
Nov 3, 2012·PloS One·Charles H GreenbergSteven M Greenberg
Nov 5, 2010·Cleveland Clinic Journal of Medicine·Joshua N Goldstein, Steven M Greenberg
Dec 24, 2013·Current Treatment Options in Neurology·Carter Gerard, Katharina M Busl
Dec 17, 2014·British Journal of Anaesthesia·P Fogarty Mack
Sep 10, 2014·Clinical Neurology and Neurosurgery·Jeremy K KamBernard Yan
Jun 27, 2009·Acta neurochirurgica·Ruediger GerlachKlaus Goerlinger
Apr 2, 2015·International Journal of Cardiology·Makrides Constantinos, Symeonides Marios
Sep 15, 2012·Emergency Medicine Clinics of North America·J Alfredo Caceres, Joshua N Goldstein
Nov 1, 2011·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·O Erhabor, T C Adias
Feb 10, 2010·Disease-a-month : DM·Philip B Gorelick, Sean Ruland
May 12, 2011·International Journal of Stroke : Official Journal of the International Stroke Society·Luca MasottiDomenico Prisco
Dec 13, 2012·International Journal of Stroke : Official Journal of the International Stroke Society·Juha HuhtakangasMatti Hillbom
May 20, 2015·Archives of Medical Research·Svjetlana ŠupeNada Božina
Apr 25, 2015·Neurologic Clinics·Allyson Zazulia
May 11, 2016·Journal of Trauma Nursing : the Official Journal of the Society of Trauma Nurses·Abigail R BlackmoreCharles W Mains
Jun 12, 2013·Journal of Intensive Care Medicine·Ivan Rocha Ferreira da Silva, J Javier Provencio
Apr 22, 2011·Journal of Pharmacy Practice·Stephen RolfeKatherine P Cabral
Mar 25, 2010·Anesthesia and Analgesia·Justine Elliott, Martin Smith
Jul 16, 2010·Acta Anaesthesiologica Scandinavica·P I JohanssonN H Secher
Sep 14, 2016·Biomédica : revista del Instituto Nacional de Salud·Ricardo A CifuentesEsperanza Avella-Vargas
Mar 23, 2011·Acta Anaesthesiologica Scandinavica·M L VangH B Ravn
Apr 17, 2020·Hospital Practice·A Shaun RoweLeslie A Hamilton
May 1, 2020·Journal of Molecular Neuroscience : MN·Ainur B TokshilykovaZhusupbek K Satenov
Feb 11, 2019·ACS Biomaterials Science & Engineering·Ye HeShilei Hao
Dec 30, 2009·Current Opinion in Neurology·George NtaiosPatrik Michel

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