Warm blood hyperkalaemic reperfusion ('hot shot') prevents myocardial substrate derangement in patients undergoing coronary artery bypass surgery

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
M CaputoG D Angelini

Abstract

A significant metabolic derangement occurs in the ischaemic-reperfused heart of patients undergoing coronary artery bypass surgery using cold blood cardioplegia. The aim of the present study was to investigate whether this effect could be reversed by complementing cold blood cardioplegia with a short terminal exposure of warm blood hyperkalaemic cardioplegia ('hot shot'). Thirty-five patients undergoing primary elective coronary revascularisation were randomized to one of two different techniques of myocardial protection. In the cold blood group (n = 17) myocardial protection was induced using antegrade hyperkalaemic cold blood cardioplegic solution. In the hot shot group (n = 18) this was supplemented with a short exposure to hyperkalaemic warm blood cardioplegia prior to removal of the cross clamp. Intracellular substrates (ATP and amino acids) were measured in left ventricular biopsies collected 5 min after institution of cardiopulmonary bypass, after 30 min of ischaemic arrest and 20 min after reperfusion. Biopsies taken at the end of the period of myocardial ischaemia, when compared to control, did not show any significant change in the intracellular concentration of ATP (from 2.71 +/- 0.32 to 2.43 +/- 0.37 micromol g wet ...Continue Reading

Citations

Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M S AvidanR A Sherwood
Jun 28, 2003·The Journal of Thoracic and Cardiovascular Surgery·Yoshiya ToyodaYutaka Okita
Apr 24, 2001·Pharmacology & Therapeutics·M S SuleimanE J Griffiths
Apr 29, 2009·Cardiovascular Research·Asger GranfeldtJakob Vinten-Johansen
Oct 3, 2014·BioMed Research International·Andreas HabertheuerDominik Wiedemann
Jul 14, 2012·Journal of Cardiothoracic and Vascular Anesthesia·Prakash A Patel, Nimesh D Desai
Jan 29, 2008·The Annals of Thoracic Surgery·Raimondo AscioneGianni D Angelini
Oct 29, 2005·Seminars in Thoracic and Cardiovascular Surgery·Wison Y Szeto, Thomas G Gleason
Oct 24, 2007·British Journal of Pharmacology·M-S SuleimanG D Angelini
Jun 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·P ModiM Caputo
Aug 20, 2010·Asian Cardiovascular & Thoracic Annals·Yves Durandy
Mar 23, 2006·Asian Cardiovascular & Thoracic Annals·Chareonkiat RergkliangVorapong Chowchuvech
Aug 1, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Bradley S Allen
Oct 3, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Alexander WahbaUNKNOWN EACTS/EACTA/EBCP Committee Reviewers
Feb 5, 2016·Science Advances·Glenn J TattersallWilliam K Milsom
Mar 29, 2000·Proceedings. Biological Sciences·P Koteja
Jul 1, 2020·Texas Heart Institute Journal·Taylor M JamesSotiris C Stamou
Nov 27, 2007·Molecular and Cellular Biochemistry·Hajime Imura, M-Saadeh Suleiman
Aug 31, 2018·Interactive Cardiovascular and Thoracic Surgery·Sara VolpiRavi De Silva
Jan 14, 2021·The Journal of Thoracic and Cardiovascular Surgery·Giuseppe Ambrosio, GianFranco Gensini
Jul 8, 2008·Journal of Theoretical Biology·Ming LuXin Yu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
M CaputoG D Angelini
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
M CaputoA J Bryan
Interactive Cardiovascular and Thoracic Surgery
Udo AbahRavi De Silva
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Vincenzo Cassano, Leonardo Milella
© 2022 Meta ULC. All rights reserved