Warm-up exercise suppresses platelet-eosinophil/neutrophil aggregation and platelet-promoted release of eosinophil/neutrophil oxidant products enhanced by severe exercise in men

Thrombosis and Haemostasis
Jong-Shyan WangChuen-Mao Yang

Abstract

Heterotypic platelet-eosinophil/neutrophil aggregation and subsequent release of eosinophil/neutrophil oxidant products contribute to pathogenesis of conditions such as asthma and inflammatory bowel diseases. This study investigates whether warmup exercise (WUE) affects platelet-eosinophil/neutrophil interaction mediated by high-intensity exercise (HIE). Twenty-three healthy sedentary men performed on three occasions light-intensity exercise (LIE, 40%VO(2 max) for 40 min) and HIE (80%VO(2 max) for 40 min) with and without WUE (40%VO(2 max) for 20 min). Before and immediately after exercise, platelet-eosinophil and platelet-neutrophil aggregation (PEA and PNA), reactive oxygen species production of eosinophils and neutrophils (EROS and NROS) enhanced by platelets, and adhesion molecule expression on platelets, eosinophils, and neutrophils were measured. The results of this study demonstrated that HIE enhanced PEA, PNA, and platelet-induced EROS and NROS, was accompanied by increased expressions of Mac-1 on eosinophils and neutrophils and P-selectin on platelets at 5 dyne/cm(2) of shear stress, 100 microg/ml lipopolysaccharide, and 1 microM N-formylmethionyl- leucyl-phenylalanine treatments, whereas the enhancement of HIE on plat...Continue Reading

Citations

Aug 19, 2006·Thrombosis Journal·Giuseppe LippiGian Cesare Guidi
Dec 19, 2008·Medicine and Science in Sports and Exercise·Jong-Shyan WangShu-Er Chow
Nov 12, 2015·BioMed Research International·Stefan Heber, Ivo Volf
Apr 17, 2019·Xenotransplantation·David K C CooperDavid Ayares
Oct 28, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Gamze ErtürkGökşen Kuran Aslan

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