PMID: 9160286Apr 1, 1997Paper

Was the formation of 1,25-dihydroxyvitamin D3 initially a catabolic pathway?

Medical Hypotheses
G ChevalierD Wion

Abstract

Following solar ultraviolet radiation, epidermal 7-dehydrocholesterol is converted to previtamin D3, which then undergoes a thermal isomerization into vitamin D3. The metabolism of vitamin D3, which is usually considered as an inactive compound, gives rise to the active hormone 1,25-dihydroxyvitamin D3, following two hydroxylation steps occurring in liver and kidney. Here, we propose that this anabolic pathway can also be interpreted as a catabolic one leading to the degradation of the photoproducts of 7-dehydrocholesterol, for which a specific biological role in the skin is proposed.

References

Nov 1, 1992·Endocrine Reviews·M R Walters
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Jan 1, 1988·Annual Review of Nutrition·A R Webb, M F Holick
Jan 1, 1986·Annual Review of Nutrition·M R Haussler
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Apr 1, 1993·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G WeedaD Bootsma

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