Wash interacts with lamin and affects global nuclear organization

Current Biology : CB
Jeffrey M VerboonS M Parkhurst

Abstract

The cytoplasmic functions of Wiskott-Aldrich syndrome family (WAS) proteins are well established and include roles in cytoskeleton reorganization and membrane-cytoskeletal interactions important for membrane/vesicle trafficking, morphogenesis, immune response, and signal transduction. Misregulation of these proteins is associated with immune deficiency and metastasis [1-4]. Cytoplasmic WAS proteins act as effectors of Rho family GTPases and polymerize branched actin through the Arp2/3 complex [1, 5]. Previously, we identified Drosophila washout (wash) as a new member of the WAS family with essential cytoplasmic roles in early development [6, 7]. Studies in mammalian cells and Dictyostelium suggest that WASH functions primarily in a multiprotein complex that regulates endosome shape and trafficking in an Arp2/3-dependent manner [8-11]. However, roles for classically cytoplasmic proteins in the nucleus are beginning to emerge, in particular, as participants in the regulation of gene expression [12, 13]. Here, we show that Drosophila Wash is present in the nucleus, where it plays a key role in global nuclear organization. wash mutant and knockdown nuclei disrupt subnuclear structures/organelles and exhibit the abnormal wrinkled mo...Continue Reading

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Citations

Aug 26, 2015·Nucleus·Jeffrey M VerboonSusan M Parkhurst
Aug 1, 2015·Experimental Cell Research·Beata FuchsovaPrimal de Lanerolle
Mar 11, 2016·Nucleus·Richik N MukherjeeDaniel L Levy
Jul 15, 2015·Biochemical and Biophysical Research Communications·Hiroshi KitamuraMasahiko Harata
Jun 25, 2017·Journal of Cell Science·Olga AlekhinaDaniel D Billadeau
May 26, 2017·Journal of Cellular Physiology·Vincent J ToccoTanmay P Lele
Mar 27, 2015·Molecular Biology of the Cell·Christopher M GroenTina L Tootle
Nov 17, 2017·Molecular Biology of the Cell·Andrew D StephensJohn F Marko
Mar 6, 2015·Molecular Biology of the Cell·Jeffrey M VerboonSusan M Parkhurst
Apr 19, 2018·Traffic·Jing WangDaniel D Billadeau
Jun 7, 2020·Journal of Cell Science·Jeffrey M VerboonSusan M Parkhurst
Jun 22, 2018·Nature·Christopher P CaridiIrene Chiolo
Mar 14, 2019·Nature Communications·Sergey V UlianovYuri Y Shevelyov
May 16, 2019·Experimental Biology and Medicine·Jeyantt SankaranJanet Rubin
Jan 29, 2021·Cellular and Molecular Life Sciences : CMLS·Eliya Bitman-Lotan, Amir Orian
Dec 19, 2017·The Journal of Allergy and Clinical Immunology·Koustav SarkarYatin M Vyas

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