Washed versus unwashed red blood cells for transfusion for the prevention of morbidity and mortality in preterm infants

The Cochrane Database of Systematic Reviews
Amy K KeirMichael J Stark

Abstract

Infants born very preterm often receive multiple red blood cell (RBC) transfusions during their initial hospitalisation. However, there is an increasing awareness of potential adverse effects of RBC transfusions in this vulnerable patient population. Modification of RBCs prior to transfusion, through washing with 0.9% saline, may reduce these adverse effects and reduce the rate of significant morbidity and mortality for preterm infants and improve outcomes for this high-risk group. To determine whether pre-transfusion washing of RBCs prevents morbidity and mortality in preterm infants. We used the standard search strategy of the Cochrane Neonatal Review Group to search the Cochrane Central Register of Controlled Trials (CENTRAL 2015, Issue 7), MEDLINE via PubMed (31 July 2015), EMBASE (31 July 2015), and CINAHL (31 July 2015). We also searched clinical trials databases, conference proceedings, and the reference lists of retrieved articles for randomised controlled trials and quasi-randomised trials. Randomised, cluster randomised, and quasi-randomised controlled trials including preterm infants (less than 32 weeks gestation) or very low birth weight infants (less than 1500 g), or both, who received one or more washed packed RBC...Continue Reading

References

Jan 1, 1997·European Journal of Pediatrics·R W CookeC James
Apr 17, 2003·JAMA : the Journal of the American Medical Association·Dean FergussonStan Shapiro
Jul 13, 2005·Archives of Ophthalmology·UNKNOWN International Committee for the Classification of Retinopathy of Prematurity
Nov 2, 2006·Transfusion·Alan TinmouthUNKNOWN Canadian Critical Care Trials Group
Feb 13, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Christine G SwindellRobert G Willetts
Sep 8, 2009·The Journal of Pediatrics·Olga A ValievaSandra E Juul
Apr 15, 2011·The Journal of Pediatrics·Amélia Miyashiro Nunes dos SantosUNKNOWN Brazilian Network on Neonatal Research
Sep 20, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jill M CholetteNeil Blumberg
Jan 28, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Carmen GiannantonioCostantino Romagnoli
May 30, 2012·British Journal of Haematology·Vidheya VenkateshSimon Stanworth
Aug 8, 2012·The Journal of Trauma and Acute Care Surgery·Ritha M BelizaireTimothy A Pritts
Sep 8, 2012·Journal of Perinatology : Official Journal of the California Perinatal Association·N RashidR J Baier
Sep 18, 2012·Blood Cells, Molecules & Diseases·Katie L LannanNeil Blumberg
Mar 12, 2013·Archives of Disease in Childhood. Fetal and Neonatal Edition·Michael J StarkChad C Andersen
Feb 11, 2014·The Cochrane Database of Systematic Reviews·Kirstin L WilkinsonMichael F Murphy

❮ Previous
Next ❯

Citations

Jul 8, 2020·Vox Sanguinis·Rebecca CardiganStephen Thomas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.