Nov 7, 2014

WASP: allele-specific software for robust discovery of molecular quantitative trait loci

BioRxiv : the Preprint Server for Biology
Bryce van de GeijnJonathan K Pritchard

Abstract

Allele-specific sequencing reads provide a powerful signal for identifying molecular quantitative trait loci (QTLs), however they are challenging to analyze and prone to technical artefacts. Here we describe WASP, a suite of tools for unbiased allele-specific read mapping and discovery of molecular QTLs. Using simulated reads, RNA-seq reads and ChIP-seq reads, we demonstrate that our approach has a low error rate and is far more powerful than existing QTL mapping approaches.

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Mentioned in this Paper

Computer Software
Quantitative Trait Loci
WAS gene
Chromatin Immunoprecipitation
Sequencing
Wiskott-Aldrich Syndrome Protein
WAS wt Allele
Mapping, Vessel
Simulation
Alleles

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