PMID: 9445192Jan 28, 1998Paper

Watchful waiting or watchful progression?: Prostate specific antigen doubling times and clinical behavior in patients with early untreated prostate carcinoma

Cancer
D B McLarenT Pickles

Abstract

Prostate specific antigen doubling time (PSAdt) is a dynamic model of prostate tumor biology. It predicts aggressive disease and subsequent clinical recurrence after radical treatment. However, as yet there is only limited evidence for its validity in the watchful waiting population. One hundred and thirteen previously untreated patients with adenocarcinoma of the prostate who were referred to the British Columbia Cancer Agency for a management opinion subsequently were placed into a prospective watchful waiting program. The reasons for watchful waiting, previous medical history, serial PSA, and histopathologic data were recorded. The median age of patients was 75 years (range, 49-85 years). The median follow-up from the time of the first appointment was 14 months (range, 0-58 months). The reasons for watchful waiting were correlated highly with T classification (P = 0.003) and past medical history (P = 0.002). Approximately 40% of T1 patients and 51% of T2 patients had clinical progression by 2 years, increasing to 60% at 3 years. On multivariate analysis PSAdt strongly correlated with clinical progression (P < 0.0001), stage progression (P = 0.01), and time to treatment (P = 0.0001); tumor grade and initial stage were not fou...Continue Reading

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Citations

Apr 29, 2008·European Urology·Michelle L RamírezChristopher P Evans
Nov 11, 2003·Critical Reviews in Oncology/hematology·Sergio VillaPatrizia Olmi
Feb 15, 2008·Der Urologe. Ausg. A·M GraefenH Huland
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Nov 3, 2009·ANZ Journal of Surgery·Ruban ThanigasalamPrem Rashid
Nov 18, 2003·BJU International·F H SchröderC H Bangma
Feb 10, 2004·The Journal of Urology·Hongyan WuDouglas Soderdahl
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Mar 17, 2004·The Journal of Urology·Manish I PatelPeter T Scardino
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Feb 8, 2006·Urology·Shomik SenguptaEric J Bergstralh
Dec 19, 2003·The Urologic Clinics of North America·Edward M Messing, Ian Thompson
Jan 18, 2011·The Journal of Urology·Luigi BenecchiMichele Potenzoni
Apr 18, 2007·The Journal of Urology·Marc Dall'Era, Peter R Carroll
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