PMID: 5653882May 1, 1968

Water and electrolyte secretion by the perfused pancreas of the cat

The Journal of Physiology
R M CaseT Scratcherd

Abstract

1. A technique is described for perfusing the isolated cat pancreas with saline solutions.2. Single doses of secretin, although present in the perfusate for only a short time, caused a prolonged flow of pancreatic juice.3. In response to continuous secretin infusion, the preparation secreted for up to 6 hr a juice which was similar to that obtained in vivo, with the exception that the bicarbonate concentration decreased and the chloride concentration increased with time, even when the rate of secretion remained constant.4. The osmolalities of perfusate and secretion were identical over a range of 450 m-osmoles/kg, but the electrolyte concentration of the secretion was always slightly higher than that of the perfusate. Variations from perfusate isosmolality produced inverse changes in the secretion rate, over the range from 600 m-osmoles/kg, at which secretion ceased, to 150 m-osmoles/kg, at which the rate was highest. At perfusate osmolalities below 150 m-osmoles/kg secretion rapidly declined.5. Reduction in perfusate sodium chloride concentration, isosmolality being maintained with sucrose, caused a fall in secretion rate, but the sodium concentration of the juice remained constant until perfusate sodium concentration was redu...Continue Reading

Citations

Jan 1, 1982·The Journal of Membrane Biology·M Bundgaard, T Zeuthen
Oct 1, 1988·The Journal of Membrane Biology·M A GrayB E Argent
Jul 27, 2006·The Journal of Membrane Biology·B BurghardtM C Steward
Feb 1, 1977·Irish Journal of Medical Science·J J MurphyP FitzGerald
Sep 1, 1981·Digestive Diseases and Sciences·M C Noel-JorandH Sarles
Nov 1, 1995·Digestive Diseases and Sciences·C MarteauA Gerolami
Jul 1, 1977·The Histochemical Journal·T Katsuyama, S S Spicer
May 1, 1976·The American Journal of Digestive Diseases·J P PascalA Ribet
Aug 26, 1998·The Journal of Physiology·H IshiguroR M Case
Jul 1, 1971·The Journal of Surgical Research·W W FergusonA M Lefer
Jul 1, 1982·Acta Physiologica Scandinavica·M Raeder, O Mathisen
Jan 1, 1980·Annals of the New York Academy of Sciences·I Schulz
May 1, 1981·Acta Physiologica Scandinavica·M Raeder, O Mathisen
Jan 1, 1979·American Journal of Surgery·H A ReberL W Way
Jan 1, 1983·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·C J SimpsonD C Carter
Jan 1, 1973·Pflügers Archiv : European journal of physiology·V Wizemann, I Schulz
Jan 1, 1971·Pflügers Archiv : European journal of physiology·I Schulz
Jan 1, 1969·Pflügers Archiv : European journal of physiology·I SchulzM Weske
Jan 1, 1971·Pflügers Archiv : European journal of physiology·I SchulzK J Ullrich
Jul 22, 1982·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·G Whittembury, B S Hill
Sep 1, 1979·The Japanese Journal of Surgery·S Teranishi, K Okajima
Jul 1, 1973·Gut·T Scratcherd, R M Case
Apr 12, 1972·Nature: New Biology·C H Swanson, A K Soilomon
Oct 28, 2010·The Journal of Biological Chemistry·Ivana NovakSusanne E Hede
Oct 19, 2013·Physiological Reviews·Helle H DamkierJeppe Praetorius
Jul 1, 1972·Journal of Clinical Psychology·R B CattellA Bjerstedt
Jan 30, 1978·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E HeidbrederA Heidland
Jul 14, 1975·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E HeidbrederA Heidland
Dec 11, 1975·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E HeidbrederA Heidland
Aug 16, 1977·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·E HeidbrederA Heidland

Related Concepts

Carbonic Acid Ions
Felis catus
Chloride Ion Level
Electrolytes
Pancreas
Pancreatic Juice
Perfusion
Potassium
Secrepan
Sodium

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Computational Methods for Protein Structures

Computational methods employing machine learning algorithms are powerful tools that can be used to predict the effect of mutations on protein structure. This is important in neurodegenerative disorders, where some mutations can cause the formation of toxic protein aggregations. This feed follows the latests insights into the relationships between mutation and protein structure leading to better understanding of disease.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.