Water and T-maze protocols are equally efficient methods to assess spatial memory in 3xTg Alzheimer's disease mice

Behavioural Brain Research
K E DavisJ Gigg

Abstract

Rodent spatial memory is commonly tested using the water-maze; however, there is a potential confound of stress on learning in this behavioural paradigm. This is particularly relevant when testing spatial memory in models of neurodegeneration, such as the 3xTg mouse model for Alzheimer's disease. Here, we first confirmed that 3xTgAD mice express fear conditioning and then compared the performance of young and middle-aged mice on short-duration versions of the radial arm water-maze (RAWM) and the minimally stressful T-maze spontaneous alternation task. Our main questions were: (1) does the reliance on stressors in water-maze training mask the true cognitive ability of 3xTgAD mice; and (2) are 3xTgAD mice similarly impaired in water-maze and T-maze protocols. Firstly, male and female 3xTgAD mice displayed intact freezing responses in both contextual and Pavlovian fear conditions. As male 3xTgAD mice displayed relatively enhanced fear responses the remaining tests were performed using only female 3xTgAD and control mice in order to equate for response to stressors. We found that alternation rates after both short and long delays were impaired at both ages in female 3xTgAD mice, indicative of robust spatial working memory deficits....Continue Reading

References

Nov 1, 1988·Behavioural Brain Research·A Ennaceur, J Delacour
May 30, 2001·Neurobiology of Aging·M N GordonG W Arendash
Feb 12, 2002·Neuroscience and Biobehavioral Reviews·Robert Lalonde
Feb 12, 2005·Proceedings of the National Academy of Sciences of the United States of America·Salvatore OddoFrank M LaFerla
Mar 21, 2006·ILAR Journal·Kathleen R BaileyJacqueline N Crawley
Apr 5, 2007·Nature Protocols·Robert M J Deacon, J Nicholas P Rawlins
Jul 31, 2007·Neurobiology of Disease·Lani K ClintonFrank M LaFerla
Nov 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jenna C CarrollChristian J Pike
May 27, 2008·Psychoneuroendocrinology·Chadi ToumaRainer Landgraf
May 29, 2008·Proceedings of the National Academy of Sciences of the United States of America·Francesca CacucciJohn O'Keefe
Aug 30, 2008·Behavioral Neuroscience·Susanna PietropaoloBenjamin K Yee
Oct 4, 2008·Behavioural Brain Research·Maria GulinelloDonald S Faber
Jan 24, 2009·Behavioural Brain Research·Sheng-Siang Jheng, Ming-Chyi Pai
Jun 30, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Kathryn NicholCarl W Cotman
Mar 4, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carola RombergLisa M Saksida
Oct 23, 2013·Behavioural Brain Research·R Baeta-Corral, L Giménez-Llort

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Citations

Sep 8, 2017·Neuropathology and Applied Neurobiology·K E Ameen-AliJ Berwick
Oct 24, 2019·Journal of Alzheimer's Disease : JAD·Keren NitzanHanna Rosenmann
Feb 6, 2019·Scientific Reports·Alina C StimmellAaron A Wilber
Nov 27, 2018·Journal of Alzheimer's Disease : JAD·Tauqeerunnisa SyedaClaudia Perez-Cruz
Jan 26, 2021·Journal of Alzheimer's Disease : JAD·Daniel Cuervo-ZanattaClaudia Perez-Cruz

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