Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery

Nature Communications
Guiyang ZhangXudong Jia

Abstract

Covalent organic frameworks (COFs) as drug-delivery carriers have been mostly evaluated in vitro due to the lack of COFs nanocarriers that are suitable for in vivo studies. Here we develop a series of water-dispersible polymer-COF nanocomposites through the assembly of polyethylene-glycol-modified monofunctional curcumin derivatives (PEG-CCM) and amine-functionalized COFs (APTES-COF-1) for in vitro and in vivo drug delivery. The real-time fluorescence response shows efficient tracking of the COF-based materials upon cellular uptake and anticancer drug (doxorubicin (DOX)) release. Notably, in vitro and in vivo studies demonstrate that PEG-CCM@APTES-COF-1 is a smart carrier for drug delivery with superior stability, intrinsic biodegradability, high DOX loading capacity, strong and stable fluorescence, prolonged circulation time and improved drug accumulation in tumors. More intriguingly, PEG350-CCM@APTES-COF-1 presents an effective targeting strategy for brain research. We envisage that PEG-CCM@APTES-COF-1 nanocomposites represent a great promise toward the development of a multifunctional platform for cancer-targeted in vivo drug delivery.

References

May 17, 2003·Nature Reviews. Drug Discovery·Ruth Duncan
Nov 19, 2005·Science·Adrien P CôtéOmar M Yaghi
Mar 28, 2006·Biochemical Pharmacology·Bharat B Aggarwal, Shishir Shishodia
Nov 15, 2007·Molecular Pharmaceutics·Preetha AnandBharat B Aggarwal
Feb 12, 2009·ACS Nano·Omid C Farokhzad, Robert Langer
Jul 21, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Ratul Kumar DasUtpal Bora
Oct 8, 2009·Journal of the American Chemical Society·Kathryn M L Taylor-PashowWenbin Lin
Jun 12, 2010·Angewandte Chemie·Axel SchlossbauerThomas Bein
Oct 27, 2011·Journal of the American Chemical Society·San-Yuan DingWei Wang
Mar 7, 2012·Applied Microbiology and Biotechnology·Jianzhi WangPingping Hou
Jul 24, 2012·Chemical Society Reviews·Xiao FengDonglin Jiang
Oct 13, 2012·Chemical Society Reviews·San-Yuan Ding, Wei Wang
May 23, 2013·Nature Chemistry·John W Colson, William R Dichtel
Jun 21, 2014·Nature Chemistry·Hong Xu, Donglin Jiang
Jun 26, 2014·Journal of the American Chemical Society·Long ChenDonglin Jiang
Jul 24, 2014·Nature Communications·Qianrong FangYushan Yan
Nov 21, 2014·Journal of the American Chemical Society·Mona CalikThomas Bein
Jun 24, 2015·Journal of the American Chemical Society·Qianrong FangYushan Yan
Oct 23, 2015·ACS Applied Materials & Interfaces·Shouying LiChangfeng Wu
Dec 29, 2015·Journal of the American Chemical Society·Zhenjie ZhangSeth M Cohen
Feb 16, 2016·Chemical Communications : Chem Comm·Linyi BaiYanli Zhao
Feb 16, 2016·Journal of the American Chemical Society·San-Yuan DingWei Wang
Feb 26, 2016·Biomacromolecules·Martin G O'TooleAndrea S Gobin
Sep 2, 2016·Journal of the American Chemical Society·Hai-Sen XuWei Wang
Sep 14, 2016·Journal of the American Chemical Society·Xiuren WangYong Cui
Oct 12, 2016·ACS Central Science·Catherine R MulzerWilliam R Dichtel
Nov 5, 2016·Journal of the American Chemical Society·Luke A BaldwinPsaras L McGrier
Dec 10, 2016·Journal of the American Chemical Society·Qi SunShengqian Ma
Apr 4, 2017·Chemical Society Reviews·Takashi KitaoTakashi Uemura

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Citations

Feb 9, 2019·Chemistry : a European Journal·Sainan LiuJun Lin
Mar 30, 2019·Chemical Communications : Chem Comm·Fu-Zhi CuiXin Zhao
Jan 30, 2020·Chemical Society Reviews·Zhifang WangShengqian Ma
Dec 28, 2019·Chemistry : a European Journal·Qun GuanYu-Bin Dong
May 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guiyang ZhangXudong Jia
May 20, 2020·Chemical Society Reviews·Rong-Ran LiangXin Zhao
Apr 26, 2020·Chemistry : a European Journal·Saud Asif AhmedKang Wang
Dec 12, 2019·Chemical Communications : Chem Comm·Bin WangJinmao You
Aug 28, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hamideh Rezvani AlanaghZhiyong Tang
Jan 30, 2019·Advanced Science·Yanpei SongShengqian Ma
Aug 6, 2019·Frontiers in Pharmacology·Yanping LiJinhan He
Jul 28, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Zhimei He, Jun-Jie Zhu
Oct 31, 2020·Chemical Communications : Chem Comm·Peng GaoBo Tang
Nov 26, 2020·Chemical Society Reviews·Da-Wen SunJi Ma
Nov 28, 2020·Angewandte Chemie·Yusen LiLong Chen
Feb 3, 2021·Chemical Communications : Chem Comm·Xiaoli YanLong Chen
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Rajeshkumar AnbazhaganHsieh-Chih Tsai
Feb 3, 2021·Angewandte Chemie·Hyuna JoKou Okuro
Mar 16, 2021·Advanced Science·Anjaiah Nalaparaju, Jianwen Jiang
Mar 30, 2021·Bioconjugate Chemistry·Yijing ZhangJuan Diwu
Apr 27, 2021·ACS Nano·Qiuhong ZhangYanli Zhao
Apr 29, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cristian ValenzuelaJianhua Zhang
Apr 27, 2021·Nano Today·Jinping WangHongjun Wang
May 18, 2021·Chemical Science·Farah BenyettouAli Trabolsi
Jul 20, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Chunyang Liao, Sijin Liu

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Methods Mentioned

BETA
nuclear magnetic resonance
transmission electron microscopy
electron diffraction
dynamic light scattering
X-ray
thermal treatment
Flow
xenograft
fluorescence imaging
column chromatography

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