PMID: 9421754Jan 1, 1997Paper

Water fugacity in absorbing polymers

Journal of Biomedical Materials Research
K J L Burg, S W Shalaby

Abstract

Absorbable biomaterials, as dynamic systems, require special handling, processing, and characterization techniques beyond those of the traditional nonabsorbable materials. As the material degrades or absorbs, in vitro or in vivo, it undergoes structural, physical, and chemical changes. These changes in the base material may significantly impact the performance of a particular biomedical device; hence, it is important that the investigator consider the full range of properties that constitute the lifetime of a given absorbable material. The long term degradation study presented here sought to identify one such property, the change in water retention of a degrading oriented polylactide film. The investigation found through differential scanning calorimetry that later stages of degradation are often characterized by a stronger retention of water, potentially due to a higher number of polar carboxyl groups within the relatively hydrophobic polymer matrix.

References

May 1, 1995·Journal of Pharmaceutical and Biomedical Analysis·A G Hausberger, P P DeLuca
Feb 1, 1993·Journal of Biomedical Materials Research·H L LinD Grubb

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Citations

Jun 24, 1999·Journal of Biomedical Materials Research·L LuA G Mikos
Jul 8, 2000·Biomaterials·L LuA G Mikos
Feb 24, 2001·Journal of Biomedical Materials Research·P Mainil-VarletU Schlegel

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