Aug 28, 2013

Water in Photosystem II: structural, functional and mechanistic considerations

Biochimica Et Biophysica Acta
Katrin Linke, Felix M Ho

Abstract

Water is clearly important for the functioning of Photosystem II (PSII). Apart from being the very substrate that needs to be transported in this water oxidation enzyme, water is also vital for the transport of protons to and from the catalytic center as well as other important co-factors and key residues in the enzyme. The latest crystal structural data of PSII have enabled detailed analyses of the location and possible function of water molecules in the enzyme. Significant progress has also been made recently in the investigation of channels and pathways through the protein complex. Through these studies, the mechanistic significance of water for PSII is becoming increasingly clear. An overview and discussion of key aspects of the current research on water in PSII is presented here. The role of water in three other systems (aquaporin, bacteriorhodopsin and cytochrome P450) is also outlined to illustrate further points concerning the central significance that water can have, and potential applications of these ideas for continued research on PSII. It is advocated that water be seen as an integral part of the protein and far from a mere solvent.

  • References122
  • Citations29

References

  • References122
  • Citations29

Citations

Mentioned in this Paper

Taurochenodeoxycholate 6alpha-hydroxylase Activity
Plastoquinol
Biochemical Pathway
Cytochrome C Oxidase
Crystal - Body Material
Dioxygen
Photosynthetic Reaction Centers
Bacteriorhodopsins
Thylakoid Membrane
Hyrex Brand of Dimenhydrinate

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