PMID: 1459Jan 1, 1976

Water regulation by a presumptive hormone contained in identified neurosecretory cell R15 of Aplysia

The Journal of General Physiology
I Kupfermann, K R Weiss

Abstract

Injection of an homogenate of identified neuron R15 into the hemocele of Aplysia produced a weight increase of 3-10% within 90 min. Control injections of several other identified neurons or of seawater, were ineffective. The weight increase occurred even when the animals were maintained in 5% hyperosmotic seawater. The activity of the R15 homogenate was retained after acidification to pH 2 and heating to 100 degrees C; but activity was destroyed by proteolytic digestion with Pronase. Dialysis in cellulose dialysis tubing resulted in a significant loss of aion on Sephadex G-50 (nominal exclusion limits 1,500-30,000 daltons), activity was present in the partially included volumes, but was absent in the totally excluded or totally included volumes. The data support the notion that R15 contains one or more hormones involved in ionic regulation or water balance. The results of bioassays of R15 extracts subjected to different treatments are consistent with the hypothesis that activity is due to one or more stable polypeptides of relatively low molecular weight.

Citations

Mar 1, 1987·Cell and Tissue Research·J M ThelerA J Baertschi
Jan 1, 1984·Neir̆ofiziologiia = Neurophysiology·O N Osipenko
Sep 1, 1992·Journal of Neurocytology·M Martinez-PadrónK Lukowiak
May 6, 1985·Brain Research·A R Rittenhouse, C H Price
Jan 1, 1985·Progress in Biophysics and Molecular Biology·W B Adams, J A Benson
Oct 1, 1996·Behavioural Brain Research·B Peretz, M Srivatsan
Jan 1, 1984·Progress in Neurobiology·K S Rózsa
May 1, 1984·Behavioral and Neural Biology·A J SussweinS Markovich
Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W D BrantonE Mayeri
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K R WeissI Kupfermann
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·W SossinR H Scheller
Mar 1, 1986·The Journal of Cell Biology·T KreinerR H Scheller
Jun 1, 1976·The Journal of General Physiology·F Strumwasser, D L Wilson
Jan 1, 1983·Annual Review of Biochemistry·L F Reichardt, R B Kelly
Jun 1, 1977·Hoppe-Seyler's Zeitschrift für physiologische Chemie·Y P LohH Gainer
Sep 1, 1979·Journal of Neurobiology·R W Berry, Y Geinisman
Sep 15, 1987·Experientia·J Koester, U T Koch
Jan 1, 1987·Journal of Neurobiology·R O Brown, E Mayeri
May 15, 1988·Experientia·E A MarcusT J Carew
Sep 11, 2018·Frontiers in Endocrinology·Anthony W Martillotti, Pei-San Tsai

Related Concepts

Molecular Sieve Chromatography
Physical Dialysis
Hormones
Hydrogen-Ion Concentration
Mollusca
Neurons
Corpus Cardiacum
Polypeptides
Pronase
Water-Electrolyte Balance

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