Water retention and drainage in different brands of microcrystalline cellulose: effect of measuring conditions

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Ioannis NikolakakisS Malamataris

Abstract

Interaction between water and microcrystalline cellulose (MCC) measured as retention and cumulative drainage of water (WR% and CDW%) is investigated for unmilled and micronized standard (Avicel and Emcocel) and silicified (Prosolv) MCC brands. A centrifuge method was applied with increasing duration and different porosity and thickness of cylindrical powder beds (specimens), in order to establish optimal determination conditions and quantify alterations in interaction between water and different MCC brands. Also, changes of specimen thickness due to presence of water (swelling) were followed. It was found that the effect of specimen porosity and thickness on water drainage (CDW%) appears to be opposite to that on water retention (WR%), while two patterns of WR% and CDW% change with specimen porosity and thickness can be distinguished depending on the centrifugation time. Also, WR% and CDW% are affected by the MCC brand and the micronization. Unmilled silicified MCC brand (Prosolv) shows significantly lower retention and higher drainage of water compared to standard unmilled brands (Avicel and Emcocel), while differences between the unmilled standard Avicel and Emcocel brands are not easily distinguished. Micronization, in gener...Continue Reading

References

Jun 26, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·T Suzuki, H Nakagami
Oct 21, 1999·International Journal of Pharmaceutics·G Tomer, J M Newton
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Feb 13, 2001·International Journal of Pharmaceutics·S R Levis, P B Deasy
Jun 24, 2003·Journal of Pharmaceutical Sciences·Kyriakos KachrimanisStavros Malamataris
Dec 18, 2003·Drug Development and Industrial Pharmacy·Christina GustafssonChrister Nyström
Feb 6, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Kyriakos Kachrimanis, Stavros Malamataris
Mar 12, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·S Almeida PrietoF J Otero Espinar

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Citations

Jun 21, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chao ChenShuwen Hu

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