Water-solid interactions. III. Effect of glass transition temperature, Tg, and processing on tensile strength of compacts of lactose and lactose/polyvinyl pyrrolidone

Pharmaceutical Development and Technology
L StubberudC Graffner

Abstract

The effect of moisture sorption at different relative humidities on the tensile strength and the physical stability of compacts of crystalline and partly amorphous lactose, alone and in binary mixtures with PVP, has been studied. Furthermore, the role of moisture as a plasticizer and its effect on the glass transition temperature, Tg, are related to the compactibiltiy. Samples were conditioned for 2 hr using a climate test chamber at different relative humidities. Moisture sorption was determined, the radial crushing strength for compacts was measured immediately and after storage, and the tensile strength was calculated. The glass transition temperature, Tg, was determined using DSC. The tensile strength of the compacts was found to depend on both the conditioning humidity and the humidity during storage. An increase in humidity to a level at which the glass transition temperature, Tg, fell below the operating temperature, T, resulted in transition from a rigid glassy state to a mobile rubbery state. For compacts of partly amorphous lactose, an increase in the tensile strength was observed during storage of tablets, due to recrystallization of the amorphous regions above Tg. Tablets of mixtures of lactose and PVP exhibit a sha...Continue Reading

References

Sep 1, 1977·Journal of Pharmaceutical Sciences·M J PikalJ E Lang
May 1, 1970·Journal of Pharmaceutical Sciences·J T Fell, J M Newton
Nov 1, 1985·Pharmaceutical Research·R HüttenrauchP Zielke

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Citations

Dec 29, 2006·Drug Development and Industrial Pharmacy·Paul M YoungDan Burnett
Sep 13, 2012·Drug Development and Industrial Pharmacy·John RojasVijay Kumar
Aug 25, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Saad M AlshahraniMichael A Repka
Aug 4, 2001·Pharmaceutical Development and Technology·M A Repka, J W McGinity
Jul 8, 1998·Pharmaceutical Development and Technology·L StubberudC Graffner
Sep 5, 2006·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Ines Zurdo SchroederClaus-Michael Lehr
Aug 5, 2004·Journal of Dairy Science·M E C ThomasS Desobry

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