Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents.

Chemical Communications : Chem Comm
Sandra Estalayo-AdriánThorfinnur Gunnlaugsson

Abstract

Two water-soluble amphiphilic Ru(ii) polypyridyl complexes containing N-1,10-phenanthrolin-5-yldocosanamide and 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ligands were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and displayed phototoxicity against HeLa cervical cancer cells.

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Citations

Oct 7, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Sandra Estalayo-AdriánThorfinnur Gunnlaugsson

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Methods Mentioned

BETA
column chromatography
fluorescence microscopy
confocal microscopy
NMR

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