Water-Soluble Compounds from Lentinula edodes Influencing the HMG-CoA Reductase Activity and the Expression of Genes Involved in the Cholesterol Metabolism

Journal of Agricultural and Food Chemistry
Alicia Gil-RamírezCristina Soler-Rivas

Abstract

A water extract from Lentinula edodes (LWE) showed HMG-CoA reductase inhibitory activity but contained no statins. NMR indicated the presence of water-soluble α- and β-glucans and fucomannogalactans. Fractions containing derivatives of these polysaccharides with molecular weight down to approximately 1 kDa still retained their inhibitory activity. Once digested LWE was applied to Caco2 in transport experiments, no significant effect was noticed on the modulation of cholesterol-related gene expression. But, when the lower compartment of the Caco2 monolayer was applied to HepG2, some genes were modulated (after 24 h). LWE was also administrated to normo- and hypercholesterolemic mice, and no significant lowering of serum cholesterol levels was observed; but reduction of triglycerides in liver was observed. However, LWE supplementation modulated the transcriptional profile of some genes involved in the cholesterol metabolism similarly to simvastatin, suggesting that it could hold potential as a hypolipidemic/hypocholesterolemic extract, although further dose-dependent studies should be carried out.

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Aug 19, 2015·Journal of Agricultural and Food Chemistry·Víctor CazCristina Soler-Rivas

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Citations

Nov 28, 2017·Food & Function·Alicia Gil-RamírezCristina Soler-Rivas
Jul 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kumar Ganesan, Baojun Xu
Sep 24, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xinyu JiYongyan Wang
Aug 24, 2021·Current Treatment Options in Rheumatology·Emma Weeding, Eleni Tiniakou
Aug 15, 2021·European Journal of Clinical Investigation·Adriana FontesAnabela Marisa Azul
Dec 11, 2021·Journal of Food Biochemistry·Jackson IsharaJohn Kinyuru

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