Water-Soluble Nanoparticle Receptors Supramolecularly Coded for Acidic Peptides

Chemistry : a European Journal
Shixin Fa, Yan Zhao

Abstract

Sequence-specific recognition of peptides is of enormous importance to many chemical and biological applications, but has been difficult to achieve due to the minute differences in the side chains of amino acids. Acidic peptides are known to play important roles in cell growth and gene expression. In this work, we report molecularly imprinted micelles coded with molecular recognition information for the acidic and hydrophobic side chains of acidic peptides. The imprinted receptors could distinguish acidic amino acids from other polar and nonpolar amino acids, with dissociation constants of tens of nanomolar for biologically active peptides containing up to 18 amino acids.

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Citations

Nov 13, 2018·Journal of Molecular Recognition : JMR·Shize Zhang, Yan Zhao
Apr 5, 2019·Chemical Communications : Chem Comm·Roshan W Gunasekara, Yan Zhao
Jan 1, 2018·Supramolecular Chemistry·M D ArifuzzamanYan Zhao
Feb 24, 2019·Bioorganic & Medicinal Chemistry Letters·Shixin Fa, Yan Zhao
Mar 17, 2021·Angewandte Chemie·Xiaowei LiYan Zhao
Jun 1, 2021·Chembiochem : a European Journal of Chemical Biology·Yan Zhao
Dec 3, 2019·Chemical Science·Yongchao YaoShiyong Zhang
Sep 24, 2019·The Journal of Organic Chemistry·Likun Duan, Yan Zhao
Jul 9, 2019·Chemistry of Materials : a Publication of the American Chemical Society·Shixin Fa, Yan Zhao
Jan 5, 2021·Journal of the American Chemical Society·Xiaowei LiYan Zhao

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