Water-soluble photopolymerizable chitosan hydrogels for biofabrication via two-photon polymerization

Acta Biomaterialia
Olga KufeltBoris N Chichkov

Abstract

Fabrication of three-dimensional (3D) hydrogel microenvironments with predefined geometry and porosity can facilitate important requirements in tissue engineering and regenerative medicine. Chitosan (CH) is well known as a biocompatible hydrogel with prospective biological properties for biomedical aims. So far, microstructuring of this soft material presents a great limitation for its application as functional supporting material for guided tissue formation. Enabling photopolymerization, chemically modified CH can be applied for the biofabrication of reproducible 3D scaffolds using rapid prototyping techniques like two-photon polymerization (2PP) or others. The application of this technique allows precise serial fabrication of computer-designed microstructure geometries by scanning a femtosecond laser beam within a photosensitive material. This work explores a new synthesis of water-soluble photosensitive chitosan and the fabrication of well-defined microstructures from the generated materials. To modulate the mechanical and biochemical properties of the material, CH was combined and cross-linked with synthetic poly(ethylene glycol) diacrylate. For a biological adaption to the in vivo situation, CH was covalently crosslinked w...Continue Reading

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Jan 18, 2014·Biomacromolecules·Olga KufeltBoris N Chichkov

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Citations

Jan 4, 2019·Acta Crystallographica. Section D, Structural Biology·Rana AshkarJeremy C Smith
Feb 23, 2019·Advanced Materials·Marc HipplerMartin Bastmeyer
Jan 13, 2018·Biofabrication·Irina Alexandra PaunCatalin Romeo Luculescu
Jan 12, 2019·Tissue Engineering. Part B, Reviews·Nicole HauptmannKlaus Liefeith
Aug 14, 2019·Small·Marco Carlotti, Virgilio Mattoli
May 13, 2020·Polymers·Wiktoria Tomal, Joanna Ortyl
Mar 14, 2021·Carbohydrate Polymers·Mina RajabiM Azam Ali
Apr 2, 2021·Biomacromolecules·Erwan Nicol
Jul 15, 2020·Chemical Reviews·Mihyun LeeMarcy Zenobi-Wong

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