Water soluble polyhydroxyalkanoates: future materials for therapeutic applications

Chemical Society Reviews
Zibiao Li, Xian Jun Loh

Abstract

Polyhydroxyalkanoates (PHAs) are excellent candidate biomaterials due to their exceptional biodegradability and biocompatibility. However, PHAs need to have tunable hydrophilicity, chemical functionalities, and appropriate hydrolytic stability to expand their therapeutic applications towards more advanced areas. In this Tutorial Review, we present the most recent progress in the synthetic strategies of PHA-based water soluble polymers, including the functionalisation of PHAs with polar functional groups and the block/graft copolymerization of PHAs with hydrophilic components in various polymeric architectures. These chemically modified water soluble PHAs have significant impact on materials engineering and show great value in the fulfilment of smart biomaterials in emerging areas. The applications of water soluble PHAs in controlled drug release, cancer therapy, DNA/siRNA delivery and tissue engineering in new aspects are discussed. In addition, water soluble PHA monomer production will be briefly introduced, with emphasis on its bio-significance in medical physiology and the therapeutic effect in the treatment of diseases.

References

Sep 1, 1994·JPEN. Journal of Parenteral and Enteral Nutrition·M KatayamaT Sugimoto
Sep 10, 2002·Biomacromolecules·François Ravenelle, Robert H Marchessault
May 14, 2003·Biomacromolecules·François Ravenelle, Robert H Marchessault
Mar 15, 2005·Biomacromolecules·Shan ChengGuo-Qiang Chen
Mar 15, 2005·Biomacromolecules·Estelle RenardPhilippe Guérin
Jun 11, 2005·Biomaterials·Guo-Qiang Chen, Qiong Wu
Dec 6, 2006·Applied Microbiology and Biotechnology·Baki Hazer, Alexander Steinbüchel
Jul 24, 2008·Biomacromolecules·Jeff Sparks, Carmen Scholz
Jul 23, 2009·Chemical Society Reviews·Guo-Qiang Chen
Nov 19, 2009·Chemical Communications : Chem Comm·Han-Nah KimYoung-Rok Kim
Apr 16, 2010·Applied Microbiology and Biotechnology·Qun RenManfred Zinn
Jul 5, 2011·Brain & Development·Mi-Sun YumDong Wook Kim
Mar 20, 2012·Journal of Colloid and Interface Science·Julien BabinotValérie Langlois
Sep 11, 2012·Macromolecular Rapid Communications·Gaëlle Le FerEstelle Renard

❮ Previous
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Citations

Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Hong Chen GuoXian Jun Loh
Jan 23, 2016·Chemistry : a European Journal·Ghislaine BaroutiSophie M Guillaume
Nov 26, 2015·The EPMA Journal·Ana C FonsecaJorge F J Coelho
Oct 21, 2015·Biomaterials Science·Xian Jun LohG Roshan Deen
Mar 13, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zoi PiperigkouAristidis M Tsatsakis
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Zibiao Li, Swee Liang Wong
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Huijie Zhang, Xiao-Dong Gao
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Fang LanZhongwei Gu
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Fuben XuJinmin Zhao
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Bo LiXiaoling Liao
Sep 15, 2015·Biomacromolecules·Xinyi SuXian Jun Loh
Sep 30, 2015·Biomaterials Science·Xiaoying Zhu, Xian Jun Loh
Mar 22, 2016·Expert Opinion on Biological Therapy·Ahad MokhtarzadehMohammad Ramezani
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Y KeG Wu
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Yonggang XiangHao Chen
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Danyang Wang, Lin-Ping Wu
Apr 16, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Nowsheen GoonooDhanjay Jhurry
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Thu Thao Nguyen ThiDai Hai Nguyen
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Jingyu YangXingdong Zhang
Feb 3, 2016·Chemistry, an Asian Journal·Anis Abdul KarimXian Jun Loh
Oct 27, 2016·Advanced Healthcare Materials·Yun-Long WuXian Jun Loh
Sep 7, 2016·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zibiao Li, Xian Jun Loh
May 10, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Zibiao LiYun-Long Wu
May 10, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Yi DingXianqun Fan
May 10, 2017·Materials Science & Engineering. C, Materials for Biological Applications·Chizhu Ding, Zibiao Li
Jul 22, 2017·Therapeutic Delivery·Zibiao Li
May 4, 2018·Chemical Society Reviews·Hongye YeXian Jun Loh
May 24, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Kun XueXian Jun Loh
Jun 6, 2018·Macromolecular Rapid Communications·Zheng LuoYun-Long Wu
Jan 16, 2019·Applied Microbiology and Biotechnology·Akhilesh Kumar SinghSatarudra Prakash Singh
Sep 10, 2019·Expert Opinion on Drug Delivery·David UlkoskiVenkata R Krishnamurthy
Aug 14, 2019·Polymers·Justyna Możejko-CiesielskaKarolina Szacherska
Dec 14, 2019·Biomaterials Science·Kun XueXian Jun Loh
Oct 19, 2017·Canadian Journal of Microbiology·James GillisBruce A Ramsay
Dec 7, 2019·Biomaterials Science·Jie YuJing Ruan
Mar 25, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lei FanYuxin Wang

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