PMID: 7547190Apr 1, 1995Paper

Water-suppressed one-dimensional 1H NMR chemical shift imaging of the heart before and after regional ischemia

NMR in Biomedicine
J A BalschiGerald M Pohost

Abstract

This study tests the hypothesis that brief periods of ischemia result in an increase in myocardial lipids during early reperfusion. We conducted 1H NMR spectroscopy to serially measure myocardial lipids before and after regional ischemia. Localized 1H NMR spectra (spatial resolution of 1.25 mm) were obtained using a one-dimensional chemical shift imaging technique. Two regions, the subendocardium and the subepicardium, were estimated by summing spectral areas from three slices (3.75 mm). Two groups of dogs that underwent a 45 min ischemia and 4 h reperfusion were studied: a group in which the myocardium beneath the surface coil underwent ischemia and reperfusion; and a group in which the ischemic event was distant from the tissue under the surface coil. Microsphere measurements showed significant blood flow reductions in the subepicardium and subendocardium in the ischemic zones during coronary occlusion. Flow returned to baseline values during reperfusion. In the ischemic zone group, the subendocardium, the triglyceride resonance areas decreased by 24% (p < 0.05) during reperfusion. However, subepicardial triglyceride areas were unchanged. Subendocardial creatine areas were also unchanged. The non-ischemic zone group subendoca...Continue Reading

References

Nov 1, 1978·Cardiovascular Research·G J JesmokH F Hardman
May 1, 1992·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J A BalschiG M Pohost
Jun 24, 1989·Molecular and Cellular Biochemistry·X Q Huang, A J Liedtke
Jun 1, 1987·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K T HolmesC E Mountford
Aug 1, 1985·Journal of the American College of Cardiology·M SchwaigerM E Phelps
Aug 1, 1985·Journal of the American College of Cardiology·M SchwaigerM E Phelps
Oct 1, 1985·Journal of Molecular and Cellular Cardiology·H JodalenJ Lekven
Jul 1, 1973·The American Journal of Cardiology·A SchwartzM Suzuki
Dec 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·L C StewartJ F Nédélec
Aug 11, 1993·Biochimica Et Biophysica Acta·M C MaddenP E Wolkowicz

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Citations

Jan 22, 2009·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Darren K McGuireLidia S Szczepaniak
Feb 21, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Lidia S SzczepaniakRonald G Victor

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