PMID: 11745790Dec 18, 2001Paper

Water vapor absorption into amorphous sucrose-poly(vinyl pyrrolidone) and trehalose-poly(vinyl pyrrolidone) mixtures

Journal of Pharmaceutical Sciences
J Zhang, G Zografi

Abstract

Previous studies from this laboratory suggested that a solution model (Flory-Huggins equation) modified by a free volume model (Vrentas equation) could satisfactorily describe water absorption into an amorphous solid composed of a sugar or a polymer. This paper has extended the studies of single solutes to binary mixtures of trehalose-and sucrose-poly(vinyl pyrrolidone) (trehalose-PVP and sucrose-PVP, respectively) either co-lyophilized or individually lyophilized and then physically mixed. Water vapor absorption isotherms of the binary mixtures were determined at 30 degrees C. Co-lyophilized PVP-sugar mixtures take up essentially the same amount of water as predicted by the weight average of individual isotherms, whereas sugar crystallization is significant retarded in the molecular dispersions. The sugar-PVP interaction, as reflected in the Flory-Huggins chi interaction parameter, was estimated by fitting the high relative pressure (p/p(0)) region of the isotherm, at which the system is in a liquid state, with a three-component Flory-Huggins-type model. The estimated sugar-water PVP-water, and sugar-PVP interaction parameters suggest that the solute-water interactions are not significantly affected by the sugar-PVP interactio...Continue Reading

References

Apr 3, 1999·Journal of Pharmaceutical Sciences·L S Taylor, G Zografi

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Citations

Sep 8, 2006·Pharmaceutical Research·Paul M Bummer, Mehran Yazdanian
Dec 14, 2012·Faraday Discussions·Ashim K DattaAlexander Warning
May 25, 2011·Journal of Pharmaceutical Sciences·David E AlonzoLynne S Taylor
Sep 11, 2013·Journal of Pharmaceutical Sciences·Ulrike StangeHenning Gieseler
Sep 25, 2004·Journal of Pharmaceutical Sciences·Tamaki MiyazakiShigeo Kojima
Nov 16, 2004·International Journal of Pharmaceutics·Tue HansenKirsten Schultz
Oct 14, 2003·Carbohydrate Research·Marie-Astrid OttenhofImad A Farhat
Jul 11, 2006·International Journal of Pharmaceutics·Denny MahlinGöran Alderborn
Mar 13, 2013·Pharmaceutical Development and Technology·Mohamed K GhorabLynne S Taylor
Apr 23, 2014·International Journal of Pharmaceutics·Kateřina PunčochováFrantišek Stěpánek
Oct 13, 2015·International Journal of Pharmaceutics·Wanjing Li, Graham Buckton
Oct 9, 2007·Journal of Pharmaceutical Sciences·Koreyoshi ImamuraKazuhiro Nakanishi
Dec 3, 2016·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Maria C PaisanaJoão F Pinto
Feb 7, 2018·Journal of Food Science·Juan O SanchezLisa J Mauer
Sep 29, 2017·Pharmaceutical Research·Hitesh S Purohit, Lynne S Taylor
Aug 14, 2020·Pharmaceutics·Thao T D Tran, Phuong H L Tran
Aug 19, 2007·Biomacromolecules·Job UbbinkHans-Jörg Limbach
Jul 29, 2009·Molecular Pharmaceutics·Alfred C F RumondorLynne S Taylor
Jun 29, 2021·Physical Chemistry Chemical Physics : PCCP·Ekaterina BogdanovaVitaly Kocherbitov

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