Water-vapor plasma-based surface activation for trichlorosilane modification of PMMA

Langmuir : the ACS Journal of Surfaces and Colloids
Timothy M LongJeffrey S Moore

Abstract

Separation rates and resolutions within capillary electrophoretic (CE) systems can be enhanced when surface zeta potentials are uniform with minimum deviations from ideal pluglike flow. Microfluidic CE devices based on poly(methyl methacrylate) (PMMA) are being developed due to the optical clarity, availability, stability, and reproducible electroosmotic flow (EOF) rates displayed by this polymer. Control of EOF in polymer-based CE systems can be achieved by surface zeta potential alteration through chemical modification. Herein, a method will be presented for the surface functionalization of PMMA with chemistry analogous to formation of trichlorosilane self-assembled monolayers on SiO2. The current method involves two separate steps. First, surface activation with water-vapor plasma introduces surface hydroxylation. Second, treatment of the plasma-treated PMMA with a substituted trichlorosilane solution forms the functional surface layer. The modified surfaces were characterized using several analytical techniques, including water contact angle, X-ray photoelectron spectroscopy, Fourier transform infrared-attenuated total reflection, secondary ion mass spectroscopy, and measurement of EOF velocities within PMMA microchannels.

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Citations

Jan 26, 2010·Expert Opinion on Drug Delivery·Carmen Alvarez-LorenzoAngel Concheiro
Oct 30, 2012·Colloids and Surfaces. B, Biointerfaces·Yunki LeeKi Dong Park
Jun 29, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Yanyan ZhengLifang Zhang
Jun 5, 2015·Soft Matter·Kaushik K RangharajanShaurya Prakash
Feb 6, 2015·Biomedical Microdevices·Agnieszka Mech-DoroszJenny Emnéus
Mar 19, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Yinyong LiKenneth R Carter
Jul 22, 2018·The Analyst·Kaushik K RangharajanShaurya Prakash
Mar 2, 2021·Journal of Extracellular Vesicles·Lucia CasadeiShaurya Prakash
May 20, 2008·Analytical Chemistry·Steffen M Weidner, Sarah Trimpin
Jun 12, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Megan A CattertonRebecca R Pompano

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