Waterborne exposure to bisphenol F causes thyroid endocrine disruption in zebrafish larvae

Chemosphere
Guo-min HuangFu-jian Ji

Abstract

While bisphenol F (BPF) has been frequently detected in various environmental compartments, limited information is available on its effect on thyroid endocrine system. In the present study, zebrafish (Danio rerio) embryos were exposed to 0.2, 2, 20, and 200 μg/L of BPF from 2 h post-fertilization (hpf) to 144 hpf. The whole-body content of thyroid hormones, thyroid-stimulating hormone (TSH), and transcription of genes belonging to the hypothalamic-pituitary-thyroid (HPT) axis were investigated. BPF exposure resulted in alterations of both T3 and T4 contents, increased the ratios of T3/T4, demonstrating thyroid endocrine disruption. Moreover, TSH content was significantly induced in a concentration-dependent manner after exposure to BPF. The increased gene transcription of dio2 might assist to degrade increased T3 contents. Treatment with BPF also significantly increased transcription of genes involved in thyroid hormone regulation (crh) and synthesis (nis and tg) as a compensatory mechanism for the decrease of T4 contents. However, the gene encoding protein involved in TH transport (ttr) was transcriptionally significantly down-regulated after exposure to BPF. Taken together, these results suggest that BPF alters the transcript...Continue Reading

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Citations

Jan 10, 2020·Environmental Science and Pollution Research International·Rania Abdelrahman ElgawishHeba M A Abdelrazek
Dec 31, 2019·Endocrinology and Metabolism·Min Joo Kim, Young Joo Park
Apr 17, 2020·International Journal of Environmental Research and Public Health·Francesca GoriniFabrizio Bianchi
Apr 19, 2021·Ecotoxicology and Environmental Safety·Kristen G HarnettSonya M Schuh
May 30, 2021·Environmental Pollution·ZhiChao DangAude Kienzler
Jul 9, 2021·Environmental Toxicology and Pharmacology·Rubén D Díaz-MartínMiguel Betancourt-Lozano
Jul 31, 2021·Ecotoxicology and Environmental Safety·Yushu QiuLisu Huang
Aug 6, 2021·Environmental Science and Pollution Research International·Qiuxu WangXueqiang Zhu
Aug 20, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Qian YangLihong Chen

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