Waterpipe smoke and e-cigarette vapor differentially affect circadian molecular clock gene expression in mouse lungs

PloS One
Naushad Ahmad KhanIrfan Rahman

Abstract

The use of emerging tobacco products, such as waterpipe or hookah and electronic cigarettes (e-cigs), has gained significant popularity and are promoted as safer alternatives to conventional cigarettes. Circadian systems are internal biological oscillations that are considered important regulators of immune functions in mammals. Tobacco induced inflammatory lung diseases frequently exhibit time-of-day/night variation in lung function and symptom severity. We investigated the impact of inhaled e-cig vapor and waterpipe smoke (WPS) on pulmonary circadian molecular clock disruption by determining the changes in expression levels and abundance of core clock component genes (BMAL1, CLOCK) and clock-controlled output genes (Rev-erbα, Per2, Rev-erbβ, Cry2, Rorα) in mouse lungs. We showed that the expression levels of these pulmonary core clock genes and clock-controlled output genes were altered significantly following exposure to WPS (Bmal1, Clock, and Rev-erbα). We further showed a significant yet differential effect on expression levels of core clock and clock-controlled genes (Bmal1, Per2) in the lungs of mice exposed to e-cig vapor containing nicotine. Thus, acute exposure to WPS and e-cig vapor containing nicotine contributes to...Continue Reading

References

Jun 11, 1998·Psychoneuroendocrinology·B F O'HaraJ D Miller
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·C M Spengler, S A Shea
Jul 28, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stephan GebelThomas Müller
Dec 14, 2007·Nature·Jun HirayamaPaolo Sassone-Corsi
Oct 11, 2008·PLoS Computational Biology·Jun YanChunxuan Shao
Nov 21, 2009·Integrative Cancer Therapies·Vihas T VasuKishorchandra Gohil
Feb 13, 2010·Annual Review of Physiology·David K WelshSteve A Kay
Mar 17, 2010·FEBS Letters·Aziz SancarNuri Ozturk
Jul 7, 2010·Journal of Occupational Medicine and Toxicology·Anke van MarkBarbara Kalsdorf
Apr 1, 2011·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Martin K RerianiAmir Lerman
Feb 9, 2012·Journal of Korean Academy of Nursing·Jeongsoon LeeJungsook Choi
Apr 10, 2012·Annual Review of Neuroscience·Jennifer A MohawkJoseph S Takahashi
Jun 9, 2012·Journal of Applied Physiology·Hélène HaddenDonald Massaro
Aug 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mary L SpenglerMarina P Antoch
Aug 25, 2012·Cell Cycle·Shobhan GaddameedhiAziz Sancar
Sep 13, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jae-Woong HwangIrfan Rahman
Jun 10, 2014·FEBS Letters·I Robinson, A B Reddy
Apr 24, 2015·American Journal of Respiratory Cell and Molecular Biology·Hongwei YaoIrfan Rahman
Sep 13, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Isaac K SundarIrfan Rahman
Jan 26, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·John H HwangLaura E Crotty Alexander
Jan 21, 2017·International Journal of Environmental Research and Public Health·Pengcheng SongYongjie Wei
Oct 5, 2017·Biochemical and Biophysical Research Communications·Isaac K SundarIrfan Rahman
Nov 4, 2017·Free Radical Biology & Medicine·Isaac K SundarIrfan Rahman
Feb 9, 2018·Physiological Reports·Naushad Ahmad KhanIrfan Rahman
Mar 14, 2018·The Journal of Clinical Investigation·Marie PariollaudDavid W Ray
Aug 12, 2018·Scientific Reports·Saika MinegishiHiroaki Kitagishi

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Citations

Aug 28, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ariane LechasseurMathieu C Morissette
Apr 21, 2020·Frontiers in Endocrinology·Shuang ZhouHou-Zao Chen
Sep 26, 2020·The Journal of Physiology·MuChun TsaiLaura E Crotty Alexander
Nov 18, 2020·Experimental Lung Research·Mario F PerezCheryl Oncken
Oct 6, 2020·Mayo Clinic Proceedings·Shahrukh K HashmiJames Taylor Hays
Jan 29, 2022·Antioxidants & Redox Signaling·Andreas DaiberThomas Münzel

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Methods Mentioned

BETA
ELISA
PCR

Software Mentioned

GraphPad Prism
Scireq flexiware

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