Watertight Robust Osteoconductive Barrier for Complex Skull Base Reconstruction: An Expanded-endoscopic Endonasal Experimental Study

Neurologia Medico-chirurgica
Alhusain NagmKazuhiro Hongo

Abstract

Endoscopic skull base reconstruction (ESBR) following expanded-endoscopic endonasal approaches (EEA) in high-risk non-ideal endoscopic reconstructive candidates remains extremely challenging, and further innovations are still necessary. Here, the aim is to study the reconstructive knowledge gap following expanded-EEA and to introduce the watertight robust osteoconductive (WRO)-barrier as an alternative durable option. Distinctively, we focused on 10 clinical circumstances. A 3D-skull base-water system model was innovated to investigate the ESBR under realistic conditions. A large-irregular defect (31 × 89 mm) extending from the crista galli to the mid-clivus was achieved. Then, WRO-barrier was fashioned and its tolerance was evaluated under stressful settings, including an exceedingly high (55 cmH2O) pressure, with radiological assessment. Next, the whole WRO-barrier was drilled to examine its practical-safe removal (simulating redo-EEA) and the whole experiment was repeated. Finally, WRO-barrier was kept into place to value its 18-month long-term high-tolerance. Results in all experiments of WRO-barriers were satisfactorily fashioned to conform the geometry of the created defect under realistic circumstances via EEA, tolerated...Continue Reading

References

Nov 1, 1987·Neurosurgery·S KobayashiK Sugita
Jan 1, 1983·The British Journal of Ophthalmology·I PerlmanA Schramek
Mar 6, 2007·The Laryngoscope·Carl SnydermanDaniel M Prevedello
May 22, 2008·Journal of Surgical Oncology·Carl H SnydermanArlan Mintz
Feb 18, 2010·Oral and Maxillofacial Surgery Clinics of North America·Amol M BhatkiAmin B Kassam
Mar 2, 2010·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Kentaro Mori
Apr 8, 2010·Physics in Medicine and Biology·T S KanekoJ H Keyak
Apr 28, 2010·The Laryngoscope·Adam J LuginbuhlMarc Rosen
Sep 9, 2010·The Laryngoscope·Carlos M Rivera-SerranoRicardo L Carrau
Nov 3, 2010·American Journal of Otolaryngology·Christopher R GrindleMarc R Rosen
Oct 8, 2011·Otolaryngologic Clinics of North America·Carl H SnydermanPaul A Gardner
Jun 19, 2013·The Laryngoscope·Carlos D Pinheiro-NetoCarl H Snyderman
Aug 21, 2013·Acta Biomaterialia·E VorndranU Gbureck
Apr 5, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Motoki InoueTetsushi Taguchi
May 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Jan LukaszczykMonika Smiga-Matuszowicz
Sep 27, 2014·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Wenting Zou, Xihui Chen
Oct 9, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Vairavan NarayananVicknes Waran
Nov 14, 2014·Neurosurgical Focus·Maria KoutourousiouPaul A Gardner
Dec 3, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Michael E IvanManish K Aghi
Dec 15, 2016·World Neurosurgery·Maria KoutourousiouPaul A Gardner
Apr 5, 2017·Otolaryngologic Clinics of North America·Aaron C SiglerRaj Sindwani
Jul 1, 2017·NMC Case Report Journal·Alhusain NagmKazuhiro Hongo
Jul 22, 2017·Journal of Neurosurgery·Joseph D ChabotJuan C Fernandez-Miranda
Aug 3, 2017·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Chiman JeonDoo-Sik Kong
Aug 22, 2017·Acta neurochirurgica·Toshihiro OgiwaraKazuhiro Hongo

❮ Previous
Next ❯

Citations

Dec 29, 2020·World Neurosurgery·Nyall R LondonPatrick C Walz

❮ Previous
Next ❯

Methods Mentioned

BETA
Dissection
X-ray

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Neurosurgical Sciences
Douglas A Hardesty, Daniel M Prevedello
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery
© 2022 Meta ULC. All rights reserved