Wattles in goats are associated with the FMN1/GREM1 region on chromosome 10

Animal Genetics
I ReberCord Drogemuller

Abstract

The presence of congenital appendages (wattles) on the throat of goats is supposed to be under genetic control with a dominant mode of inheritance. Wattles contain a cartilaginous core covered with normal skin resembling early stages of extremities. To map the dominant caprine wattles (W) locus, we collected samples of 174 goats with wattles and 167 goats without wattles from nine different Swiss goat breeds. The samples were genotyped with the 53k goat SNP chip for a subsequent genome-wide association study. We obtained a single strong association signal on chromosome 10 in a region containing functional candidate genes for limb development and outgrowth. We sequenced the whole genomes of an informative family trio containing an offspring without wattles and its heterozygous parents with wattles. In the associated goat chromosome 10 region, a total of 1055 SNPs and short indels perfectly co-segregate with the W allele. None of the variants were perfectly associated with the phenotype after analyzing the genome sequences of eight additional goats. We speculate that the causative mutation is located in one of the numerous gaps in the current version of the goat reference sequence and/or represents a larger structural variant whi...Continue Reading

References

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Dec 12, 2012·Animal Genetics·James W KijasUNKNOWN International Goat Genome Consortium
Jan 28, 2014·PloS One·Gwenola Tosser-KloppUNKNOWN International Goat Genome Consortium

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Citations

Jan 2, 2018·Journal of Dairy Science·Sebastian MuchaJoanne Conington
Apr 1, 2019·Journal of Dairy Science·D GuanM Amills
Mar 4, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Andrea TalentiUNKNOWN Italian Goat Consortium
Jun 4, 2020·Journal of Animal Science and Biotechnology·Megan ScholtensHugh Blair

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Methods Mentioned

BETA
genotyping
chip

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