Wave Intensity Analysis Provides Novel Insights Into Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension.

Journal of the American Heart Association
Junjing SuLuke S Howard

Abstract

In contrast to systemic hypertension, the significance of arterial waves in pulmonary hypertension (PH) is not well understood. We hypothesized that arterial wave energy and wave reflection are augmented in PH and that wave behavior differs between patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). Right heart catheterization was performed using a pressure and Doppler flow sensor-tipped catheter to obtain simultaneous pressure and flow velocity measurements in the pulmonary artery. Wave intensity analysis was subsequently applied to the acquired data. Ten control participants, 11 patients with PAH, and 10 patients with CTEPH were studied. Wave speed and wave power were significantly greater in PH patients compared with controls, indicating increased arterial stiffness and right ventricular work, respectively. The ratio of wave power to mean right ventricular power was lower in PAH patients than CTEPH patients and controls. Wave reflection index in PH patients (PAH: ≈25%; CTEPH: ≈30%) was significantly greater compared with controls (≈4%), indicating downstream vascular impedance mismatch. Although wave speed was significantly correlated to disease severity, wave reflec...Continue Reading

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Citations

Mar 17, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Junjing SuUlf Simonsen
Jul 14, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Michal SchäferUyen Truong
Jun 22, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Junjing SuSoren Mellemkjaer
Sep 26, 2020·Frontiers in Physiology·Jonathan P MynardJoseph J Smolich
Mar 27, 2021·Biomechanics and Modeling in Mechanobiology·Liuyang FengXiaoyu Luo
Jul 27, 2021·Frontiers in Veterinary Science·Tomohiko YoshidaRyou Tanaka
Dec 24, 2021·Circulation Journal : Official Journal of the Japanese Circulation Society·Yoshihisa Nakano, Shiro Adachi

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