Wave reflections, assessed with a novel method for pulse wave separation, are associated with end-organ damage and clinical outcomes

Hypertension
Thomas WeberBernd Eber

Abstract

We recently developed a novel method for assessment of arterial wave reflections (ARCSolver method): based on adopted Windkessel methods, flow curves are estimated from pressure waveforms, and wave separation analysis is performed, yielding the amplitudes of the forward and backward waves. The aim of this study was to investigate their clinical correlates and prognostic impact. In 725 patients (417 men; mean age, 64 years) undergoing coronary angiography, we determined wave reflections from radial tonometry and transfer function-derived aortic waveforms using pulse wave analysis, as well as wave separation analysis. Measures of pulsatile arterial function were statistically significant, although moderately associated with markers of cardiac load and subclinic cardiac, renal, and aortic end-organ damage. After a median follow-up duration of 1399 days, 139 patients reached the combined cardiovascular end point (death, myocardial infarction, stroke, coronary, cerebrovascular, and peripheral revascularization). In univariate analysis, the relative risk of the combined end point increased with increasing levels of incident pressure wave height, augmented pressure, and forward and backward wave amplitude (hazard ratio for 1 SD was 1....Continue Reading

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Citations

Aug 8, 2014·Journal of Hypertension·Francesco SteaLorenzo Ghiadoni
Nov 28, 2015·Journal of the American Society of Hypertension : JASH·Raymond R TownsendWilliam C Cushman
Jun 6, 2015·American Journal of Hypertension·Mayooran NamasivayamMichael F O'Rourke
Oct 31, 2012·Computer Methods and Programs in Biomedicine·Bernhard HametnerThomas Weber
Apr 24, 2015·American Journal of Hypertension·Arnaud T Djami-TchatchouAngela J Woodiwiss
Apr 29, 2014·The Journal of Clinical Hypertension·Siegfried WassertheurerMarcus Baumann
Jan 7, 2015·IEEE Journal of Biomedical and Health Informatics·Chang-Sei KimJin-Oh Hahn
Aug 14, 2015·Journal of Human Hypertension·P Jankowski, T Weber
Dec 10, 2013·International Journal of Cardiology·Bernhard HametnerBernd Eber
Jan 30, 2015·Journal of Hypertension·Jonathan P MynardAlberto Avolio
Mar 13, 2016·Psychophysiology·Erik J SirevaagJohn W Rohrbaugh
Dec 29, 2016·The Journal of Physiological Sciences : JPS·Anran WangDingchang Zheng
Apr 9, 2017·Annals of Vascular Surgery·Christos ArgyriouMiltos K Lazarides
Sep 28, 2017·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Yanina ZócaloDaniel Bia
Dec 23, 2017·BMC Cardiovascular Disorders·Agnes J BoschRoland E Schmieder
Nov 25, 2014·Circulation·Leroy L CooperGary F Mitchell
Apr 23, 2014·Hypertension·Gary F Mitchell
Jul 15, 2015·Hypertension·Raymond R TownsendUNKNOWN American Heart Association Council on Hypertension

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