Wavelength-dependence of vasodilation and NO release from S-nitrosothiols and dinitrosyl iron complexes by far red/near infrared light

Archives of Biochemistry and Biophysics
Agnes KeszlerNicole L Lohr

Abstract

Far red/near infrared (R/NIR) energy is a novel therapy, but its mechanism of action is poorly characterized. Cytochrome c oxidase (Cco) of the mitochondrial electron transport chain is considered the primary photoacceptor for R/NIR to photolyze a putative heme nitrosyl in Cco to liberate free nitric oxide (NO). We previously observed R/NIR light directly liberates NO from nitrosylated hemoglobin and myoglobin, and recently suggested S-nitrosothiols (RSNO) and dinitrosyl iron complexes (DNIC) may be primary sources of R/NIR-mediated NO. Here we indicate R/NIR light exposure induces wavelength dependent dilation of murine facial artery, with longer wavelengths (740, and 830 nm) exhibiting reduced potency when compared to 670 nm. R/NIR also stimulated NO release from pure solutions of low molecular weight RSNO (GSNO and SNAP) and glutathione dinitrosyl iron complex (GSH-DNIC) in a power- and wavelength-dependent manner, with the greatest effect at 670 nm. NO release from SNAP using 670 was nearly ten-fold more than GSNO or GSH-DNIC, with no substantial difference in NO production at 740 nm and 830 nm. Thermal effects of irradiation on vasodilation or NO release from S-nitrosothiols and DNIC was minimal. Our results suggest 670 nm...Continue Reading

Citations

Jun 12, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Hannah SerrageMichael R Hamblin
Aug 9, 2018·Photomedicine and Laser Surgery·Brendan J QuirkHarry T Whelan
Dec 15, 2018·Journal of Biomedical Optics·Randa ZeinMichael R Hamblin
Feb 18, 2020·Lasers in Surgery and Medicine·Lilach GavishZehava Ovadia-Blechman
Aug 10, 2019·Lasers in Medical Science·Tereza C BuzinariGerson J Rodrigues
Mar 20, 2019·Advances in Skin & Wound Care·Rodrigo Crespo MoscaPraveen Arany
Apr 18, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Simone Mitie SunemiAndrey Jorge Serra
May 29, 2021·Journal of Photochemistry and Photobiology. B, Biology·Dorothee WeihrauchNicole L Lohr
Jul 14, 2021·Nanoscale·Rachael Knoblauch, Chris D Geddes
Apr 7, 2020·The Journal of Physical Chemistry Letters·Hojeong YoonManho Lim
Sep 20, 2019·Inorganic Chemistry·Daniela R TruzziPeter C Ford

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