Wavenumber selection based analysis in Raman spectroscopy improves skin cancer diagnostic specificity

The Analyst
Jianhua ZhaoHarvey Lui

Abstract

Real-time Raman spectroscopy can be used to assist in assessing skin lesions suspicious for cancer. Most of the diagnostic algorithms are based on full band of the Raman spectra, either in the fingerprint region or the high wavenumber region. In this paper we explored wavenumber selection based analysis in Raman spectroscopy for skin cancer diagnosis. Wavenumber selection was implemented using windows of wavenumber and leave-one-out cross-validated stepwise regression or least and shrinkage selection operator (LASSO). The diagnostic algorithms were then generated from the selected windows of wavenumber using multivariate statistical analyses, including principal component and general discriminate analysis (PC-GDA) and partial least squares (PLS). In total a combined cohort of 645 confirmed lesions from 573 patients encompassing skin cancers, precancers and benign skin lesions were included, which were divided into training cohort (n = 518) and testing cohort (n = 127) according to the measurement time. It was found that the area under the receiver operating characteristic curve (ROC) was improved from 0.861-0.891 to 0.891-0.911 and the diagnostic specificity for fixed sensitivity 0.99-0.90 was improved from 0.17-0.65 to 0.20-0....Continue Reading

References

May 1, 1994·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·D L Streiner
Sep 25, 1998·Photochemistry and Photobiology·A Mahadevan-JansenR Richards-Kortum
Jul 17, 2003·Lasers in Surgery and Medicine·Shovan K MajumderPradeep K Gupta
Nov 6, 2003·International Journal of Cancer. Journal International Du Cancer·Zhiwei HuangHaishan Zeng
Sep 7, 2004·Analytical and Bioanalytical Chemistry·M ForinaC Pizarro Millan
Aug 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Abigail S HakaMichael S Feld
Aug 10, 2006·Biopolymers·M V P ChowdaryC Murali Krishna
Jul 7, 2007·Journal of Biomedical Optics·Annieke NijssenGerwin J Puppels
May 10, 2008·Journal of Biomedical Optics·Chad A LieberAnita Mahadevan-Jansen
Jun 4, 2008·Cancer Research·Nicholas Stone, Pavel Matousek
Aug 30, 2008·Lasers in Surgery and Medicine·Chad A LieberAnita Mahadevan-Jansen
Oct 22, 2008·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Jianhua ZhaoHaishan Zeng
Dec 18, 2008·Source Code for Biology and Medicine·Zoran BursacDavid W Hosmer
Oct 13, 2009·Analytical Chemistry·Jianhua MoZhiwei Huang
Aug 3, 2011·Journal of Biomedical Optics·Matthew D KellerAnita Mahadevan-Jansen
Aug 19, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Michael A ShortHaishan Zeng
Mar 22, 2012·Cancer Research·Harvey LuiHaishan Zeng
Jan 5, 2013·Journal of Biophotonics·Mads Sylvest BergholtZhiwei Huang
Mar 14, 2013·Optics Express·Michael A ShortHaishan Zeng
Aug 2, 2015·Analytical and Bioanalytical Chemistry·Jianhua ZhaoHaishan Zeng
Jan 11, 2016·Journal of Biophotonics·Hanna C McGregorHaishan Zeng

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Citations

Mar 9, 2017·Biomedical Optics Express·Soogeun KimSoo Yeol Lee
Jun 11, 2020·Applied Spectroscopy·Rekha GautamAnita Mahadevan-Jansen
Jun 9, 2020·Experimental and Therapeutic Medicine·Ioana-Alina GrajdeanuLaura Gheuca Solovastru
Oct 12, 2019·Scientific Reports·Willie C ZúñigaMichael C Storrie-Lombardi
Oct 28, 2016·Lasers in Surgery and Medicine·Milind RajadhyakshaKishwer S Nehal
Jan 19, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Fatima AlsamadOlivier Piot
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Heping LiShuang Wang
Feb 11, 2021·Experimental Dermatology·Ivan A BratchenkoValery P Zakharov
Mar 5, 2019·The Journal of Physical Chemistry. B·Yasuaki KumamotoKatsumasa Fujita
Dec 3, 2021·Journal of Biophotonics·Boris KhlebtsovNikolai Khlebtsov

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