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WDR5 modulates cell motility and morphology and controls nuclear changes induced by a 3D environment

Proceedings of the National Academy of Sciences of the United States of America

Jul 11, 2018

Pengbo WangJavier Redondo-Muñoz

Abstract

Cell migration through extracellular matrices requires nuclear deformation, which depends on nuclear stiffness. In turn, chromatin structure contributes to nuclear stiffness, but the mechanosensing pathways regulating chromatin during cell migration remain unclear. Here, we demonstrate ...read more

Mentioned in this Paper

In Vivo
Biochemical Pathway
Myosin Light Chain Kinase
2-Dimensional
Protein Methylation
Extracellular
Three-dimensional
Cell Polarity
Cell Motility
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
20
1
50

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WDR5 modulates cell motility and morphology and controls nuclear changes induced by a 3D environment

Proceedings of the National Academy of Sciences of the United States of America

Jul 11, 2018

Pengbo WangJavier Redondo-Muñoz

PMID: 29987046

DOI: 10.1073/pnas.1719405115

Abstract

Cell migration through extracellular matrices requires nuclear deformation, which depends on nuclear stiffness. In turn, chromatin structure contributes to nuclear stiffness, but the mechanosensing pathways regulating chromatin during cell migration remain unclear. Here, we demonstrate ...read more

Mentioned in this Paper

In Vivo
Biochemical Pathway
Myosin Light Chain Kinase
2-Dimensional
Protein Methylation
Extracellular
Three-dimensional
Cell Polarity
Cell Motility
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
20
1
50

Similar Papers Found In These Feeds

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