WE-E-213CD-07: Deformable Registration Between CT and Truncated CBCT for Adaptive Therapy Dose Calculation

Medical Physics
Xin ZhenSteve Jiang

Abstract

Deformable image registration (DIR) is a crucial step in adaptive radiation therapy (ART) to deform the planning CT to the current CBCT for dose calculation and for contour propagation. CBCT images are sometimes truncated in the axial plane due to limited field of view (FOV). DIR between CT and truncated CBCT often leads to unphysical results, especially in and near missing regions, which may result in significant errors in dose calculation afterwards. The purpose of this work is to develop and evaluate a method to improve existing DIR algorithms to solve the truncation problem. The radius of FOV of CBCT is first estimated. A recently developed robust CT-CBCT DIR algorithm, called Deformation with Intensity Simultaneously Corrected (DISC), is used for deformation field calculation. At each iteration of DISC, the calculated deformation vector field outside the FOV is replaced by a smooth propagation of the deformation field inside the FOV. Six head-and-neck cancer cases and two prostate cancer cases are used for evaluation. Dose calculation is performed to test the impacts on the resulting dose distribution. In terms of DIR accuracy, it is found that the average normalized mutual information (NMI), normalized cross correlation (...Continue Reading

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