WE-E-BRB-03: Development of a Deformable Dosimetric Phantom for Verification of 4D Dose Calculation Algorithms

Medical Physics
Hualiang ZhongIndrin J Chetty

Abstract

To develop a deformable lung phantom to verify voxel mapping and dose accumulation in 4D dose calculation algorithms used under different scenarios of tissue compression. The phantom consists primarily of a heterogeneous sponge with an embedded tissue-equivalent tumor. The sponge is wrapped in a latex balloon housed in a Lucite cylinder. The balloon is attached to a piston that compresses the sponge to mimic the human diaphragm. The phantom was programmed to simulate different breathing patterns. Radiochromic films and TLD were embedded in the sponge for 4D dosimetry algorithm verification. 37 anatomical landmarks were manually tracked to verify voxel mappings for four deformable image registration (DIR) algorithms: in-house developed Demons and finite element model algorithms, and two B-Spline based Velocity AI registration algorithms performed between end-inhale and end-exhale. A 6MV photon beam was simulated with BEAMnrc/DOSXYZnrc on the end-inhale image with the dose mapped to the end-exhale using voxel-based linear dose mapping (LDM) and particle-based energy-mass congruence mapping (EMCM) methods. The mean density of the artificial lung was increased by 10.2% as the sponge was compressed by 2.5cm. The reproducibility of t...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.