WE-G-213CD-02: 4D-PET Maximum Intensity Projections Improve Accuracy of Mobile Tumor Volume Delineation

Medical Physics
Shyam S JaniD A Low

Abstract

To examine the efficacy and accuracy of respiratory-gated positron emission tomography (4D-PET) maximum intensity projections (MIPs) in segmenting mobile tumor internal target volumes (ITVs) through a phantom study. An acrylic phantom was used for PET list-mode acquisition, consisting of 11C-filled spheres affixed inside a cylinder containing an 18-fluorodeoxyglucose solution. The phantom was attached to a robotic arm that underwent 1D motion based on clinically-derived patient breathing trajectories. An amplitude-based gating was performed on sequential list-mode sub-files of varying signal-to-background ratios, and PET-MIPs were generated from the gated images. ITVs were segmented by first denoising and deblurring images using a custom post-processing module and then applying an absolute SUV threshold. ITV accuracy was assessed using the volume recovery fraction (VRF) - the ratio of measured ITV to true volume occupied by the moving phantom spheres - which was used to compare PET-MIP, ungated PET, and static sphere images. In addition, the effects of tumor trajectories, number of gating windows, and margin additions were investigated. VRFs of ITVs generated from PET-MIPs were consistently higher than those from ungated PET. T...Continue Reading

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