WE-G-BRCD-09: Assessment of Quantitative Differences Between Different Deformable Image Registration Algorithms for Image Guided Radiotherapy of Head and Neck Cancer Patients

Medical Physics
Mirek FatygaS Song

Abstract

DIR algorithms differ by physical principles employed in their design which in turn determines complexity of the transformation that the algorithm allows. Indiscriminate application of different algorithms without regard for their limitations may lead to significant discrepancies in research results and in clinical procedures. We compare two different algorithms in Head and Neck (H&N) patients to assess what aspects of DIR use are most sensitive to differences between algorithms. H&N patients are enrolled in a protocol which acquires weekly FBCT and daily double CBCT. Each FBCT study is contoured by the same physician. Two DIR algorithms are compared: Small Deformation Inverse-Consistent Linear Elastic (SICLE), and the ITK Diffeomorphic Demons (ITKDD) as implemented in the ITK package. Both algorithms employ significantly different physical principles in their design and consequently impose different restrictions on the complexity of transformation they allow. We compare Jacobian Volume Histograms (JVH), Spatial Discrepancy Volume Histograms (SDVH), BED and physical dose accumulation results and resulting plan evaluation indices. Analysis of mean Jacobian shows that both algorithms are able to detect changes in structure volume...Continue Reading

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