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Weak blood group B phenotypes may be caused by variations in the CCAAT-binding factor/NF-Y enhancer region of the ABO gene

Transfusion

Sep 4, 2007

Axel SeltsamRainer Blasczyk

Abstract

Binding of CCAAT-binding factor NF-Y (CBF/NF-Y) to a 43-bp repeat unit in the minisatellite region in the 5' region of the ABO gene (CBF/NF-Y enhancer region) plays an important role in regulating the transcription of ABO genes. The common ABO alleles were found to have CBF/NF-Y enhance...read more

Mentioned in this Paper

CCAAT-Binding Factor
Blood Group H Type 1 Antigen
Minisatellite Repeats
Plasma Protein Binding Capacity
Etiology
Protein Domain
Base Sequence
Open Reading Frames
Alleles
Regulatory Sequences, Nucleic Acid
Paper Details
References
  • References21
  • Citations10
123
  • References21
  • Citations10
1

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Weak blood group B phenotypes may be caused by variations in the CCAAT-binding factor/NF-Y enhancer region of the ABO gene

Transfusion

Sep 4, 2007

Axel SeltsamRainer Blasczyk

PMID: 17764507

DOI: 10.1111/j.1537-2995.2007.01475.x

Abstract

Binding of CCAAT-binding factor NF-Y (CBF/NF-Y) to a 43-bp repeat unit in the minisatellite region in the 5' region of the ABO gene (CBF/NF-Y enhancer region) plays an important role in regulating the transcription of ABO genes. The common ABO alleles were found to have CBF/NF-Y enhance...read more

Mentioned in this Paper

CCAAT-Binding Factor
Blood Group H Type 1 Antigen
Minisatellite Repeats
Plasma Protein Binding Capacity
Etiology
Protein Domain
Base Sequence
Open Reading Frames
Alleles
Regulatory Sequences, Nucleic Acid

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CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Enhancers in Development & Diseases (Keystone)

Enhancers are short regions of the DNA which can be bound by activator or repressor proteins to affect transcription of a particular gene. This feed covers the latest research on enhancer function in development and disease.

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