Weak expression of focal adhesion kinase (pp125FAK) in patients with cervical cancer is associated with poor disease outcome

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Boris GabrielAnnette Hasenburg

Abstract

The pp125 focal adhesion kinase (FAK) plays a pivotal role in tumor cell signaling. FAK expression has been linked to tumor cell invasion and metastasis, but data on cervical cancer are inconclusive. Our goal was to investigate FAK expression in cervical cancer and to assess whether its expression correlates with prognosis. FAK expression was examined using immunohistochemistry with sections from 162 resected cervical cancer specimens. Kaplan-Meier survival curves were used to determine the significance of FAK expression in the prognosis of cervical cancer patients. Specific FAK expression was found in the tumor cells, whereas normal cervical epithelium showed barely any FAK expression. Of 162 invasive cervical cancer specimens, 55 (34%) revealed weak expression of FAK, whereas moderate and strong expression was found in 63 (39%) and 44 (27%) tumors, respectively. Patients with tumors expressing weak amounts of FAK were characterized by a significantly poorer overall survival compared with those with moderate and high intratumoral FAK expression (P = 0.002). Weak expression of FAK correlated with pelvic lymph node metastasis (P = 0.026) and recurrent disease (P = 0.013). Multivariate Cox regression analysis revealed decreased F...Continue Reading

References

Jun 1, 1991·American Journal of Obstetrics and Gynecology·M P Hopkins, G W Morley
May 1, 1997·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M ImaizumiM Hamaguchi
Dec 29, 1998·The Journal of Cell Biology·J H ZhaoJ L Guan
Dec 22, 1999·Oncogene·K MaungD C Bennett
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jan 27, 2000·Cell·T Hunter
Jul 23, 2002·Nature Cell Biology·Egle AvizienyteMargaret C Frame
Dec 6, 2002·Cancer·Galen B SchneiderMary J C Hendrix
Mar 18, 2003·Journal of Cell Science·J Thomas Parsons
Mar 28, 2003·The Biochemical Journal·Lucia BevigliaWilliam G Cance
May 2, 2003·Nature Reviews. Cancer·Peter Friedl, Katarina Wolf
Sep 25, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P MoriceD Castaigne
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H-S MoonS-C Kim
Jul 21, 2004·The Journal of Cell Biology·Hajime YanoHisataka Sabe
Nov 13, 2004·Applied Immunohistochemistry & Molecular Morphology : AIMM·Chad A LivasyRuth A Lininger
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Satyajit K MitraDavid D Schlaepfer
Feb 19, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P Boyle, J Ferlay
Feb 22, 2005·Gynecologic Oncology·D DenschlagA Hasenburg
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Jun 21, 2005·Nature Reviews. Cancer·Shoshana KleinAlexander Levitzki
Aug 3, 2005·Nature Reviews. Cancer·Gordon W McLeanMargaret C Frame
Sep 2, 2005·British Journal of Cancer·D O WatermannE Stickeler

❮ Previous
Next ❯

Citations

Jan 27, 2009·Cancer Metastasis Reviews·Jihe Zhao, Jun-Lin Guan
Oct 24, 2009·Clinical Orthopaedics and Related Research·Carlos Vinícius Buarque de GusmãoWilliam Dias Belangero
Jul 22, 2014·Pathology, Research and Practice·Dana FaingoldMiguel N Burnier
Dec 17, 2009·Expert Opinion on Therapeutic Targets·Joerg SchwockDavid W Hedley
May 15, 2010·Expert Opinion on Investigational Drugs·Alexander Schultze, Walter Fiedler
Aug 21, 2010·The American Journal of Pathology·I-Rue LaiTang-Long Shen
Jun 16, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Yan Li LiXing Xie
Aug 4, 2009·Pathology, Research and Practice·Sermin OzkalTeresa Marafioti
Jul 30, 2011·Cancer·Sebahat OcakPierre P Massion
Oct 11, 2011·The Journal of Pathology·Tanguy Lechertier, Kairbaan Hodivala-Dilke
Jan 29, 2014·Histopathology·Rosa BoschIsolda Casanova
Sep 26, 2006·Biochemical Pharmacology·Maroesja J van Nimwegen, Bob van de Water
Oct 16, 2014·Pharmacology & Therapeutics·Brian Y LeeRoger J Daly
May 14, 2016·Journal of Cellular and Molecular Medicine·Teresa Gómez Del PulgarJesús García-Foncillas
Oct 2, 2014·Nature Communications·Silvia BatistaKairbaan Hodivala-Dilke
Oct 14, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Boris GabrielAxel zur Hausen
Sep 10, 2008·The Journal of Biological Chemistry·Soraya Abouzahr-RifaiSalem Chouaib

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.