PMID: 7520984Sep 1, 1994Paper

Weak genotoxicity of acrylamide on premeiotic and somatic cells of the mouse

Mutation Research
A RussoB Simoncini

Abstract

The effects of acrylamide (AA) were evaluated, under the EEC/STEP project 'Detection of Germ Cell Mutagens', by carrying out several cytogenetic assays on mouse germ and somatic cells. The spermatid micronucleus (MN) test was applied after treatment of meiotically dividing or premeiotic S phase cells. Acute treatments (50 and 100 mg/kg i.p.) as well as subchronic exposure to AA (4 x 50 mg/kg, 4 i.p. injections at 24-h intervals) were performed. A weak increase of MN was induced only by treatment with AA of cells in S phase. Sister-chromatid exchange (SCE) analysis in differentiating spermatogonia treated i.p. with 50 and 100 mg/kg confirmed the weak genotoxicity of AA in the premeiotic stages of spermatogenesis. The application of the MN test in peripheral blood reticulocytes of the same animals used for the spermatid MN assay indicated that the cytogenetic effects induced by AA in the somatic and the germ cell lines are comparable in magnitude. The results obtained in this study by applying the spermatid micronucleus assay are in very good agreement with those reported by two other laboratories with the same technique.

References

Jan 1, 1989·Environmental and Molecular Mutagenesis·L C BackerJ W Allen
Jul 1, 1989·Mutation Research·A Neuhäuser-Klaus, W Schmahl
Nov 1, 1988·Mutation Research·I D AdlerA el Tarras
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Citations

Jan 29, 2000·Biulleten' eksperimental'noĭ biologii i meditsiny·E V NesterovaS B Seredenin
Aug 1, 1995·Mutation Research·K L DearfieldD J Brusick
Jun 12, 1996·Mutation Research·I D AdlerA D Tates
Dec 13, 2000·Mutation Research·A Russo
May 12, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·J H Exon
Sep 9, 2008·Regulatory Toxicology and Pharmacology : RTP·Michael DoursonMelissa Kohrman
May 19, 1998·Environmental and Molecular Mutagenesis·N Titenko-HollandA J Wyrobek
Feb 25, 2005·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Jeanne MansonPeter Working
Sep 16, 2006·Critical Reviews in Toxicology·A ShippC Van Landingham

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