Weakly acidic gastroesophageal refluxes are frequently triggers in young children with chronic cough

Pediatric Pulmonology
Michele GhezziMichela Silvestri

Abstract

To evaluate whether the proportion of acid and weakly acidic refluxes preceding cough bursts could be different in infants, preschool- and school-aged children with chronic, unexplained cough. One hundred six children with unexplained chronic cough, not receiving acid suppressive therapy, underwent impedance-pH monitoring. They were divided into Group A: <2 years (21 pts), Group B: ≥2 to ≤6 years (41 pts), and Group C: >6 years (44 pts). Reflux was defined as acid (pH <4), weakly acidic (WA; pH 4-7), and weakly alkaline (pH >7).Cough episodes were considered temporally associated with gastroesophageal reflux (GER) when occurring within 2 min after a GER episode. Impedance-pH detected 55.50 (39.00-76.00) reflux episodes/patient with an acid-to-WA reflux event ratio of 3.31 (1.55-8.33). This parameter was significantly lower in Group A (1.33 [0.41-3.40]) than in Group B (3.06 [2.00-6.50]; P < 0.05] and Group C (5.09 [2.34-12.43; P < 0.001]). No cough episode was preceded by weakly alkaline refluxes in any patient. During impedance-pH recording, 93 patients (87.7%) had at least one cough episode that had been preceded by impedance refluxes in 83 patients. In this latter group (83 pts), the median number of cough episodes was 12.0 ...Continue Reading

References

Sep 1, 1994·Journal of Clinical Gastroenterology·M A LaukkaA J Schei
Jul 1, 1997·The European Respiratory Journal·A B ChangC F Robertson
Sep 11, 2004·The European Respiratory Journal·A H MoriceUNKNOWN ERS Task Force
Dec 2, 2004·The American Journal of Gastroenterology·Rachel Rosen, Samuel Nurko
Feb 14, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rachel RosenSamuel Nurko
Feb 14, 2006·Paediatric Respiratory Reviews·John Massie
May 10, 2006·Archives of Internal Medicine·Tonya KaltenbachLauren B Gerson
Oct 3, 2006·The European Respiratory Journal·R P BoeschR S Amin
Oct 20, 2006·Respiratory Medicine·Claude ThilmanyMatthias Griese
Nov 15, 2006·The American Journal of Gastroenterology·Albert J BredenoordDonald O Castell
Nov 23, 2006·Digestive Diseases and Sciences·Girolamo MattioliVincenzo Jasonni
Sep 13, 2008·Archives of Disease in Childhood. Fetal and Neonatal Edition·L CorvagliaG Faldella
Jan 15, 2009·Alimentary Pharmacology & Therapeutics·V Tolia, Y Vandenplas
Jan 28, 2009·Journal of Pediatric Gastroenterology and Nutrition·Michiel P van WijkTaher I Omari
Aug 15, 2009·Journal of Pediatric Gastroenterology and Nutrition·Ruggiero FrancavillaLuciano Cavallo
Jun 3, 2010·Archives of Disease in Childhood·A B ChangP H Katelaris
Sep 11, 2010·The Journal of Pediatrics·Silvia SalvatoreYvan Vandenplas
Feb 22, 2011·Respiratory Medicine·Michele GhezziGiovanni A Rossi

❮ Previous
Next ❯

Citations

Sep 3, 2013·Current Opinion in Pediatrics·David ForbesMadhur Ravikumara
Feb 4, 2014·Pediatric Surgery International·Christoph CastellaniMichael E Höllwarth
Jun 13, 2014·Wiener klinische Wochenschrift·Angela ZacharasiewiczUNKNOWN Austrian Society of Pediatrics and The Austrian Society of Pneumology
Jun 23, 2015·Pediatric Pulmonology·Michele GhezziGiovanni A Rossi
Mar 31, 2015·International Journal of Pediatric Otorhinolaryngology·Melanie GreiferLee P Smith
Sep 16, 2014·Frontiers in Physiology·Iulia IoanSilvia Varechova
May 8, 2014·Oxidative Medicine and Cellular Longevity·Izabela Sadowska-BartoszMarta Rachel
May 28, 2019·Minerva pediatrica·Annarita BongiovanniSalvatore Leonardi
Aug 15, 2013·Journal of Pediatric Gastroenterology and Nutrition·Rachel RosenSamuel Nurko
Apr 2, 2014·Postgraduate Medicine·Claudia HalabyMelodi Pirzada
Oct 14, 2016·Pediatric Pulmonology·Letizia ZenzeriAnnamaria Staiano
May 26, 2017·PloS One·Maja JurcaClaudia E Kuehni
May 15, 2021·American Journal of Speech-language Pathology·Mary J SandageShelby C Odom

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.