Weakly and strongly associated nonfreezable water bound in bones

Colloids and Surfaces. B, Biointerfaces
V V TurovE Jagiello-Wojtowicz

Abstract

Water bound in bone of rat tail vertebrae was investigated by 1H NMR spectroscopy at 210-300 K and by the thermally stimulated depolarization current (TSDC) method at 190-265 K. The 1H NMR spectra of water clusters were calculated by the GIAO method with the B3LYP/6-31G(d,p) basis set, and the solvent effects were analyzed by the HF/SM5.45/6-31G(d) method. The 1H NMR spectra of water in bone tissue include two signals that can be assigned to typical water (chemical shift of proton resonance deltaH=4-5 ppm) and unusual water (deltaH=1.2-1.7 ppm). According to the quantum chemical calculations, the latter can be attributed to water molecules without the hydrogen bonds through the hydrogen atoms, e.g., interacting with hydrophobic environment. An increase in the amount of water in bone leads to an increase in the amount of typical water, which is characterized by higher associativity (i.e., a larger average number of hydrogen bonds per molecule) and fills larger pores, cavities and pockets in bone tissue.

References

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Feb 22, 2005·Journal of Colloid and Interface Science·V V TurovA A Chuiko

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Citations

Jan 26, 2016·Medical Hypotheses·Michael G GraySusan G Hurley
May 2, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Jeffry S NymanMark D Does
Sep 2, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R Adam HorchMark D Does
Sep 9, 2006·Colloids and Surfaces. B, Biointerfaces·V M Gun'koE Jagiello-Wojtowicz
Dec 26, 2006·Advances in Colloid and Interface Science·V M Gun'koJ P Blitz
Nov 13, 2012·Journal of Colloid and Interface Science·Miroslaw JabłońskiVladimir V Turov

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