Weakly-supervised learning for lung carcinoma classification using deep learning.

Scientific Reports
Fahdi KanavatiMasayuki Tsuneki

Abstract

Lung cancer is one of the major causes of cancer-related deaths in many countries around the world, and its histopathological diagnosis is crucial for deciding on optimum treatment strategies. Recently, Artificial Intelligence (AI) deep learning models have been widely shown to be useful in various medical fields, particularly image and pathological diagnoses; however, AI models for the pathological diagnosis of pulmonary lesions that have been validated on large-scale test sets are yet to be seen. We trained a Convolution Neural Network (CNN) based on the EfficientNet-B3 architecture, using transfer learning and weakly-supervised learning, to predict carcinoma in Whole Slide Images (WSIs) using a training dataset of 3,554 WSIs. We obtained highly promising results for differentiating between lung carcinoma and non-neoplastic with high Receiver Operator Curve (ROC) area under the curves (AUCs) on four independent test sets (ROC AUCs of 0.975, 0.974, 0.988, and 0.981, respectively). Development and validation of algorithms such as ours are important initial steps in the development of software suites that could be adopted in routine pathological practices and potentially help reduce the burden on pathologists.

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Citations

Dec 3, 2020·Journal of Clinical Medicine·J Luis Espinoza, Le Thanh Dong
Jun 11, 2021·SN Computer Science·SeyyedPooya HekmatiAtharMohd Anwar
Jun 12, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Julia R NasoAndrew Churg
Jun 18, 2021·Interdisciplinary Sciences, Computational Life Sciences·Xiaoli ZhouYanqing Shao
Jun 25, 2021·Chemical Science·Elaine C PetronilhoJerson L Silva
Jul 1, 2021·Technology in Cancer Research & Treatment·Fahdi KanavatiMasayuki Tsuneki
Aug 14, 2021·Computers in Biology and Medicine·Shuchang ZhangHongxia Wang
Aug 20, 2021·Frontiers in Research Metrics and Analytics·Shikha SinghalHarsha Gurulingappa
Sep 24, 2021·BMC Bioinformatics·Francisco Carrillo-PerezLuis Javier Herrera
Oct 16, 2021·Scientific Reports·Fahdi Kanavati, Masayuki Tsuneki
Dec 8, 2021·Current Medical Science·Peng-Ran LiuZhe-Wei Ye
Jan 26, 2022·Virchows Archiv : an International Journal of Pathology·Fahdi KanavatiMasayuki Tsuneki

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Methods Mentioned

BETA
surgical resection
biopsy

Software Mentioned

scikit
Medmain
learn
TensorFlow
matplotlib

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