Weaned pigs experimentally infected with Salmonella display sexually dimorphic innate immune responses without affecting pathogen colonization patterns

Translational Animal Science
N C Burdick SanchezSara D Lawhon

Abstract

Sexually dimorphic innate immune responses have been observed in several species, but have not been studied in response to a live pathogen challenge in pigs. This study aimed to elucidate sexually dimorphic innate immune responses along with Salmonella translocation patterns in newly weaned pigs orally inoculated with Salmonella. Newly weaned pigs (n = 8 gilts and 12 barrows; 6.2 ± 0.2 kg BW) were obtained from a commercial swine facility and were maintained in an environmentally-controlled facility in individual pens equipped with feeders and nipple waterers. Pigs were allowed ad libitum access to a commercial non-medicated starter ration and water throughout the study. On d 12 post-weaning, pigs were anesthetized to allow placement of a temperature measuring device in the abdominal cavity for measurement of intraperitoneal temperature (TEMP). On d 17, pigs were anesthetized and fitted with indwelling jugular vein catheters. On the following day (d 18), pigs were orally inoculated with 4.7×109Salmonella typhimurium. Blood samples were collected at 0.5-h intervals from -2 to 8 h, and at 8-h intervals from 8 to 72 h post-challenge. Whole blood was analyzed for complete blood cell counts. Serum was isolated for measurement of cor...Continue Reading

References

Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·F Homo-DelarcheM Dardenne
Nov 1, 1974·Biological Reviews of the Cambridge Philosophical Society·A Glucksmann
Apr 26, 2000·Laboratory Animals·J A CarrollR L Matteri
Jul 25, 2000·Journal of Animal Science·R BalajiJ E Minton
May 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Chrysoula DosiouLinda C Giudice
Nov 30, 2007·Journal of Food Protection·Shivani Ojha, Magdalena Kostrzynska
Dec 8, 2007·Epidemiology and Infection·N J C StrachanJ E Galán
Aug 25, 2015·Animal : an International Journal of Animal Bioscience·C LarzulP Mormede

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