Weaning from prolonged veno-venous extracorporeal membrane oxygenation (ECMO) after transfer to a specialized center: a retrospective study

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
Frederik SeilerPhilipp M Lepper

Abstract

Veno-venous extracorporeal membrane oxygenation (vvECMO) is increasingly used as rescue therapy in severe respiratory failure. In patients with pre-existent lung diseases or persistent lung injury weaning from vvECMO can be challenging. This study sought to investigate outcomes of patients transferred to a specialized ECMO center after prolonged ECMO therapy. We performed a retrospective analysis of all patients admitted to our medical intensive care unit (ICU) between 01/2013 and 12/2016 who were transferred from an external ICU after > 8 days on vvECMO. 12 patients on ECMO for > 8 days were identified. Prior to transfer, patients underwent ECMO therapy for 18 ± 9.5 days. Total time on ECMO was 60 ± 46.6 days. 11/12 patients could be successfully weaned from ECMO, 7/12 in the first 28 days after transfer (8 ± 8.8 ECMO-free days at day 28). In 7 patients, ECMO could be terminated after at least partial lung recovery, in 4 patients after salvage lung transplant. No patient died or needed re-initiation of ECMO therapy at day 28. In summary, weaning from vvECMO was feasible even after prolonged ECMO courses and salvage lung transplant could be avoided in most cases. Patients may benefit from transfer to a specialized ECMO center.

References

Apr 19, 2013·Critical Care : the Official Journal of the Critical Care Forum·Cecile AubronVince Pellegrino
Nov 1, 2013·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Andrew A RosenbergLena M Napolitano
Oct 12, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Christopher M SauerPramod Bonde
Nov 25, 2014·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yeon Joo LeeYoung-Jae Cho
Oct 16, 2015·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Seong Mi MoonChi Ryang Chung
Oct 23, 2015·American Journal of Respiratory and Critical Care Medicine·Franziska C TrudzinskiPhilipp M Lepper
Dec 2, 2015·Annals of Surgery·Joseph PoslusznyUNKNOWN ELSO Member Centers
Mar 5, 2016·Intensive Care Medicine·Christian KaragiannidisWolfram Windisch
May 1, 2016·The Annals of Thoracic Surgery·Fenton H McCarthyNimesh D Desai
Jun 25, 2016·The International Journal of Artificial Organs·Nina BuchteleThomas Staudinger
Jul 28, 2016·Shock·Bruno Adler Maccagnan Pinheiro Besen, Leandro Utino Taniguchi
Aug 25, 2016·The American Journal of Emergency Medicine·Evgeni BrotfainMoti Klein

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Citations

Feb 24, 2019·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Y SawaT Yamaoka
Feb 25, 2020·Expert Review of Respiratory Medicine·Soo Jin Na, Kyeongman Jeon
Jul 24, 2020·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Justyna SwolHergen Buscher

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