PMID: 9524528Apr 3, 1998Paper

Wear and osteolysis in total joint replacements

Acta Orthopaedica Scandinavica. Supplementum
Y KadoyaH Ohashi

Abstract

This presentation summarizes the results of our recent studies on the pathogenesis of osteolysis around total joint arthroplasties. First, interface tissues with adjacent bone were retrieved and histopathologically investigated with reference to the cells on the bone surface. Secondly, polyethylene particles were extracted with the tissue digestion method and characterized with scanning electron microscopy. Finally, an animal model for osteolysis was created and various interface conditions were compared concerning their resistance to particle migration. Histopathological examinations demonstrated that active bone formation, regarded as a repair process, was the commonest feature, even in revised cases. They also highlighted the role played by macrophages, not as cells producing inflammatory mediators which could activate osteoclasts, but as cells primarily responsible for the bone loss in osteolytic lesions. Among the particle species present, only polyethylene particles were shown to play a significant role in macrophage recruitment and subsequent osteolysis. A quantitative extraction of polyethylene particles showed a significant difference in the "number" of particles between osteolysis positive and negative cases whereas t...Continue Reading

References

Oct 23, 1997·The Journal of Bone and Joint Surgery. British Volume·H M Van Der VisC J Van Noorden
Apr 3, 1998·Acta Orthopaedica Scandinavica·P Aspenberg, H van der Vis

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Citations

Oct 10, 2006·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Vicente Sanchis-Alfonso
Oct 26, 1999·AORN Journal·G Carter
May 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S G KaarE M Greenfield
Jun 24, 2003·The Journal of Arthroplasty·T GosensA J Tonino
Jun 15, 2004·The Knee·C F KellettD W Murray
Mar 22, 2002·The International Journal of Biochemistry & Cell Biology·C E Evans
Jul 20, 2007·Arthritis Research & Therapy·Yousef Abu-AmerJohn C Clohisy
Oct 22, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·H H GuoQ H Jin
May 9, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Toru MoroYoshio Takatori
May 19, 2005·International Orthopaedics·T Gosens, E J van Langelaan
Jan 17, 2012·Trends in Molecular Medicine·Harinderjit S GillEleftherios Tsiridis
Nov 22, 2011·Best Practice & Research. Clinical Rheumatology·Miriam García-AriasEmilio Martín Mola
Apr 6, 2001·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·T HirayamaT Torisu
Oct 9, 2007·The Journal of Arthroplasty·Kentaro IseTakashi Nakamura
Nov 6, 2007·Clinical Radiology·J G CahirJ Nolan
Oct 1, 2004·The Journal of Arthroplasty·Michael JacobsCarleton Southworth
Dec 16, 2004·Journal of Biomechanics·A ShortD W Murray
Mar 8, 2006·The Journal of Arthroplasty·Geoffrey HorneDavid J N Dalton
Feb 4, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Dariush FirouziHabiba Bougherara
May 23, 2014·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Harry A McKellopJohn A Skinner
May 27, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Meghan M MoranDale Rick Sumner

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