Wearable Contact Lens Biosensors for Continuous Glucose Monitoring Using Smartphones

ACS Nano
Mohamed ElsherifHaider Butt

Abstract

Low-cost, robust, and reusable continuous glucose monitoring systems that can provide quantitative measurements at point-of-care settings is an unmet medical need. Optical glucose sensors require complex and time-consuming fabrication processes, and their readouts are not practical for quantitative analyses. Here, a wearable contact lens optical sensor was created for the continuous quantification of glucose at physiological conditions, simplifying the fabrication process and facilitating smartphone readouts. A photonic microstructure having a periodicity of 1.6 μm was printed on a glucose-selective hydrogel film functionalized with phenylboronic acid. Upon binding with glucose, the microstructure volume swelled, which modulated the periodicity constant. The resulting change in the Bragg diffraction modulated the space between zero- and first-order spots. A correlation was established between the periodicity constant and glucose concentration within 0-50 mM. The sensitivity of the sensor was 12 nm mM-1, and the saturation response time was less than 30 min. The sensor was integrated with commercial contact lenses and utilized for continuous glucose monitoring using smartphone camera readouts. The reflected power of the first-or...Continue Reading

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Citations

Jan 4, 2019·Advanced Healthcare Materials·Michael A VandenBerg, Matthew J Webber
May 23, 2019·Lab on a Chip·Mohamed ElsherifHaider Butt
Jun 12, 2019·Advanced Healthcare Materials·Rosalia MoredduAli K Yetisen
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Methods Mentioned

BETA
amputation
Light diffraction

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