Wearable scanning photoacoustic brain imaging in behaving rats

Journal of Biophotonics
Jianbo TangHuabei Jiang

Abstract

A wearable scanning photoacoustic imaging (wPAI) system is presented for noninvasive brain study in behaving rats. This miniaturized wPAI system consists of four pico linear servos and a single transducer-based PAI probe. It has a dimension of 50 mm × 35 mm × 40 mm, and a weight of 26 g excluding cablings. Phantom evaluation shows that wPAI achieves a lateral resolution of ∼0.5 mm and an axial resolution of ∼0.1 mm at a depth of up to 11 mm. Its imaging ability is also tested in a behaving rat, and the results indicate that wPAI is able to image blood vessels at a depth of up to 5 mm with intact scalp and skull. With its noninvasive, deep penetration, and functional imaging ability in behaving animals, wPAI can be used for behavior, cognition, and preclinical brain disease studies.

References

Dec 1, 1980·Journal of Neuroscience Methods·G PaxinosP C Emson
May 1, 1999·Journal of Neuroscience Methods·K M LahtiJ A King
Feb 15, 2003·Science·Jeffrey K ThompsonRalph D Freeman
Oct 16, 2009·Nature·Christopher D HarveyDavid W Tank
Nov 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Juergen SawinskiJason N D Kerr
Aug 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Peifang TianAnna Devor
Oct 20, 2010·Somatosensory & Motor Research·Cornelius SchwarzChristian Waiblinger
Jan 18, 2011·Nature Neuroscience·Tobi A SzutsMarkus Meister
Aug 7, 2012·Interface Focus·Paul Beard
Nov 7, 2012·Medical Physics·Zhen Yuan, Huabei Jiang
Jun 27, 2013·Nature Neuroscience·Matteo Carandini, Anne K Churchland
Jun 18, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jianbo TangHuabei Jiang
Aug 4, 2015·Nature Methods·Lim-Anna SieuIvan Cohen

❮ Previous
Next ❯

Citations

May 6, 2016·Scientific Reports·Jianbo TangHuabei Jiang
Jul 12, 2017·Journal of Biophotonics·Xianjin DaiHuabei Jiang
Jan 4, 2017·International Journal of Molecular Sciences·Bàrbara Laviña
Dec 1, 2017·Applied Sciences·Xianjin DaiHuabei Jiang
Dec 29, 2020·Physics in Medicine and Biology·Dhiman DasManojit Pramanik
Oct 27, 2018·ACS Applied Materials & Interfaces·Hyun Woo KimUnyong Jeong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.