PMID: 6690983Jan 5, 1984

Weaver mutation has differential effects on the dopamine-containing innervation of the limbic and nonlimbic striatum

S Roffler-Tarlov, A M Graybiel


Ungerstedt observed that the dopamine-containing innervation of the forebrain can be divided into two parts: a nigrostriatal system, originating mainly in the pars compacta of the substantia nigra and innervating the caudoputamen; and a mesolimbic system arising mainly in the ventral tegmental area and innervating the nucleus accumbens and olfactory tubercle. This classification has since been modified and extended with the discovery of the mesocortical dopamine system. The original distinction between nigrostriatal and mesolimbic systems nevertheless was pivotal in suggesting that the basal ganglia are related to limbic as well as to sensorimotor functions, and remains of interest because dopaminergic mechanisms may be implicated not only in the aetiology of sensorimotor impairments such as those of Parkinson's disease, but also in neuropsychiatric disorders such as schizophrenia. The striatal targets of the mesolimbic and nigrostriatal systems are now known to be distinct also in terms of forebrain connections, despite some overlap of fibre projections. The nucleus accumbens-olfactory tubercle region and abutting caudoputamen (together called the 'ventral' or 'limbic' striatum) are characteristically related to limbic parts o...Continue Reading


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Related Concepts

Pars Compacta
Limbic System
Projections and Predictions
Muscle Innervation, Function
Lentiform Nucleus Structure
Dorsal Striatum
Entire Basal Nuclei

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